Repeat tuberculin testing bcg vaccinated subjects in the UK: the booster effect varies with the time of reading.

Research output: Contribution to journalArticle

Abstract

The booster effect varies between populations, but has not been studied in the UK. The aim of this study was to investigate the effect of repeat tuberculin tests at 1 wk in BCG-vaccinated healthy subjects (all hospital employees) in the UK; we have assessed whether a booster effect is present 48 and 72 h after injection. Twenty-six subjects received two tuberculin tests (both 10 units) administered by the Mantoux technique-Tests 1 and 2. At Test 2 there was a significant increase in induration at 48 h (mean, 7.8 mm; p < 0.001), no difference at 72 h (mean, 0.2 mm; p = 0.93), and a reduction at 96 h (mean, -4.2 mm; p = 0.02). There were more positive results (> 15 mm induration) at Test 2 compared with Test 1 at 48 h (19 vs. 9, respectively; p = 0.002), but similar numbers at 72 h (11 vs. 10, respectively). These results show that repeat tuberculin testing in this BCG-vaccinated population caused a booster effect that varied with the time of measurement and was maximal at 48 h.

Bibliographical metadata

Original languageEnglish
JournalAmerican review of Respiratory & Clinical Care Medicine
Volume164(6)
Publication statusPublished - 15 Sep 2001