Regiodivergent copper catalyzed borocyanation of 1,3-dienes

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Abstract

Copper catalyzed multifunctionalization of unsaturated carbon‐carbon bonds is a powerful tool for the generation of complex molecules. We report a regiodivergent process that allows a switch between 1,4‐borocupration and 4,1‐borocupration of 1,3‐dienes upon a simple change in ligand. The subsequently generated allyl coppers are trapped in an electrophilic cyanation to selectively generate densely functionalized and synthetically versatile 1,2‐ or 4,3‐ borocyanation products.

Bibliographical metadata

Original languageEnglish
JournalAngewandte Chemie International Edition
Volume57
Issue number35
Early online date10 Jul 2018
DOIs
Publication statusPublished - 27 Aug 2018

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