Reductive cyclisations of amidines involving aminal radicals

Research output: Contribution to journalArticle

Abstract

Amidines bearing simple alkenes undergo aminal radical cyclisation upon treatment with SmI2. The mild, reductive electron transfer process delivers medicinally-relevant, polycyclic quinazolinone derivatives in good to excellent yield and typically with complete diastereocontrol.

Bibliographical metadata

Original languageEnglish
Pages (from-to)10160-10163
JournalChemical Communications
Volume54
Issue number72
Early online date15 Aug 2018
DOIs
Publication statusPublished - 2018