Reduced Iron in Diabetic WoundsCitation formats

  • External authors:
  • Holly N. Wilkinson
  • Sophie E. Upson
  • Kayleigh L. Banyard
  • Robert Knight
  • Matthew J. Hardman

Standard

Reduced Iron in Diabetic Wounds : An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling. / Wilkinson, Holly N.; Upson, Sophie E.; Banyard, Kayleigh L.; Knight, Robert; Mace, Kimberly A.; Hardman, Matthew J.

In: Journal of Investigative Dermatology, Vol. 139, No. 11, 11.2019, p. 2368-2377.e7.

Research output: Contribution to journalArticlepeer-review

Harvard

Wilkinson, HN, Upson, SE, Banyard, KL, Knight, R, Mace, KA & Hardman, MJ 2019, 'Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling', Journal of Investigative Dermatology, vol. 139, no. 11, pp. 2368-2377.e7. https://doi.org/10.1016/j.jid.2019.05.014

APA

Wilkinson, H. N., Upson, S. E., Banyard, K. L., Knight, R., Mace, K. A., & Hardman, M. J. (2019). Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling. Journal of Investigative Dermatology, 139(11), 2368-2377.e7. https://doi.org/10.1016/j.jid.2019.05.014

Vancouver

Wilkinson HN, Upson SE, Banyard KL, Knight R, Mace KA, Hardman MJ. Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling. Journal of Investigative Dermatology. 2019 Nov;139(11):2368-2377.e7. https://doi.org/10.1016/j.jid.2019.05.014

Author

Wilkinson, Holly N. ; Upson, Sophie E. ; Banyard, Kayleigh L. ; Knight, Robert ; Mace, Kimberly A. ; Hardman, Matthew J. / Reduced Iron in Diabetic Wounds : An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling. In: Journal of Investigative Dermatology. 2019 ; Vol. 139, No. 11. pp. 2368-2377.e7.

Bibtex

@article{647ef2a4fddb41ecacf20469912f52da,
title = "Reduced Iron in Diabetic Wounds: An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling",
abstract = "Iron is crucial for maintaining normal bodily function with well-documented roles in erythropoiesis, hemostasis, and inflammation. Despite this, little is known about the temporal regulation of iron during wound healing, or how iron contributes to wound biology and pathology. In this study, we profiled tissue iron levels across a healing time-course, identifying iron accumulation during late-stage repair. Diabetic murine wounds displayed significantly reduced iron levels, delayed extracellular matrix deposition, and dysregulation of iron gene expression. In vitro studies revealed important cellular roles for iron, promoting both the deposition and remodeling of extracellular proteins. Functional studies identified oxidative stress-dependent upregulation of the iron-converting metalloreductase, STEAP3, as a key mediator of extracellular matrix production. Taken together, these data reveal a mechanistic role for iron in facilitating the remodeling stage of wound healing. Indeed, targeting tissue iron could be a promising future strategy to tackle the development and progression of chronic wounds.",
author = "Wilkinson, {Holly N.} and Upson, {Sophie E.} and Banyard, {Kayleigh L.} and Robert Knight and Mace, {Kimberly A.} and Hardman, {Matthew J.}",
year = "2019",
month = nov,
doi = "10.1016/j.jid.2019.05.014",
language = "English",
volume = "139",
pages = "2368--2377.e7",
journal = "The Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "Springer Nature",
number = "11",

}

RIS

TY - JOUR

T1 - Reduced Iron in Diabetic Wounds

T2 - An Oxidative Stress-Dependent Role for STEAP3 in Extracellular Matrix Deposition and Remodeling

AU - Wilkinson, Holly N.

AU - Upson, Sophie E.

AU - Banyard, Kayleigh L.

AU - Knight, Robert

AU - Mace, Kimberly A.

AU - Hardman, Matthew J.

PY - 2019/11

Y1 - 2019/11

N2 - Iron is crucial for maintaining normal bodily function with well-documented roles in erythropoiesis, hemostasis, and inflammation. Despite this, little is known about the temporal regulation of iron during wound healing, or how iron contributes to wound biology and pathology. In this study, we profiled tissue iron levels across a healing time-course, identifying iron accumulation during late-stage repair. Diabetic murine wounds displayed significantly reduced iron levels, delayed extracellular matrix deposition, and dysregulation of iron gene expression. In vitro studies revealed important cellular roles for iron, promoting both the deposition and remodeling of extracellular proteins. Functional studies identified oxidative stress-dependent upregulation of the iron-converting metalloreductase, STEAP3, as a key mediator of extracellular matrix production. Taken together, these data reveal a mechanistic role for iron in facilitating the remodeling stage of wound healing. Indeed, targeting tissue iron could be a promising future strategy to tackle the development and progression of chronic wounds.

AB - Iron is crucial for maintaining normal bodily function with well-documented roles in erythropoiesis, hemostasis, and inflammation. Despite this, little is known about the temporal regulation of iron during wound healing, or how iron contributes to wound biology and pathology. In this study, we profiled tissue iron levels across a healing time-course, identifying iron accumulation during late-stage repair. Diabetic murine wounds displayed significantly reduced iron levels, delayed extracellular matrix deposition, and dysregulation of iron gene expression. In vitro studies revealed important cellular roles for iron, promoting both the deposition and remodeling of extracellular proteins. Functional studies identified oxidative stress-dependent upregulation of the iron-converting metalloreductase, STEAP3, as a key mediator of extracellular matrix production. Taken together, these data reveal a mechanistic role for iron in facilitating the remodeling stage of wound healing. Indeed, targeting tissue iron could be a promising future strategy to tackle the development and progression of chronic wounds.

UR - http://www.scopus.com/inward/record.url?scp=85070716594&partnerID=8YFLogxK

U2 - 10.1016/j.jid.2019.05.014

DO - 10.1016/j.jid.2019.05.014

M3 - Article

C2 - 31176711

AN - SCOPUS:85070716594

VL - 139

SP - 2368-2377.e7

JO - The Journal of Investigative Dermatology

JF - The Journal of Investigative Dermatology

SN - 0022-202X

IS - 11

ER -