Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle InductionCitation formats

  • External authors:
  • Yuhang Zhang
  • Philip Tomann
  • Thomas Andl
  • Natalie M. Gallant
  • Joerg Huelsken
  • Boris Jerchow
  • Walter Birchmeier
  • Stefano Piccolo
  • Marja L. Mikkola
  • Edward E. Morrisey
  • Paul A. Overbeek
  • Claus Scheidereit
  • Sarah E. Millar
  • Ruth Schmidt-Ullrich

Standard

Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction. / Zhang, Yuhang; Tomann, Philip; Andl, Thomas; Gallant, Natalie M.; Huelsken, Joerg; Jerchow, Boris; Birchmeier, Walter; Paus, Ralf; Piccolo, Stefano; Mikkola, Marja L.; Morrisey, Edward E.; Overbeek, Paul A.; Scheidereit, Claus; Millar, Sarah E.; Schmidt-Ullrich, Ruth.

In: Developmental cell, Vol. 17, No. 1, 21.07.2009, p. 49-61.

Research output: Contribution to journalArticlepeer-review

Harvard

Zhang, Y, Tomann, P, Andl, T, Gallant, NM, Huelsken, J, Jerchow, B, Birchmeier, W, Paus, R, Piccolo, S, Mikkola, ML, Morrisey, EE, Overbeek, PA, Scheidereit, C, Millar, SE & Schmidt-Ullrich, R 2009, 'Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction', Developmental cell, vol. 17, no. 1, pp. 49-61. https://doi.org/10.1016/j.devcel.2009.05.011

APA

Zhang, Y., Tomann, P., Andl, T., Gallant, N. M., Huelsken, J., Jerchow, B., Birchmeier, W., Paus, R., Piccolo, S., Mikkola, M. L., Morrisey, E. E., Overbeek, P. A., Scheidereit, C., Millar, S. E., & Schmidt-Ullrich, R. (2009). Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction. Developmental cell, 17(1), 49-61. https://doi.org/10.1016/j.devcel.2009.05.011

Vancouver

Zhang Y, Tomann P, Andl T, Gallant NM, Huelsken J, Jerchow B et al. Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction. Developmental cell. 2009 Jul 21;17(1):49-61. https://doi.org/10.1016/j.devcel.2009.05.011

Author

Zhang, Yuhang ; Tomann, Philip ; Andl, Thomas ; Gallant, Natalie M. ; Huelsken, Joerg ; Jerchow, Boris ; Birchmeier, Walter ; Paus, Ralf ; Piccolo, Stefano ; Mikkola, Marja L. ; Morrisey, Edward E. ; Overbeek, Paul A. ; Scheidereit, Claus ; Millar, Sarah E. ; Schmidt-Ullrich, Ruth. / Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction. In: Developmental cell. 2009 ; Vol. 17, No. 1. pp. 49-61.

Bibtex

@article{13bf75648cd74329a6df4e5872aeec2e,
title = "Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction",
abstract = "Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/β-catenin signaling requires epithelial β-catenin activity. We find that Wnt/β-catenin signaling is absolutely required for NF-κB activation, and that Edar is a direct Wnt target gene. Wnt/β-catenin signaling is initially activated independently of EDA/EDAR/NF-κB activity in primary hair follicle primordia. However, Eda/Edar/NF-κB signaling is required to refine the pattern of Wnt/β-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-κB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-κB target. These data reveal a complex interplay and interdependence of Wnt/β-catenin and EDA/EDAR/NF-κB signaling pathways in initiation and maintenance of primary hair follicle placodes. {\textcopyright} 2009 Elsevier Inc. All rights reserved.",
keywords = "DEVBIO, SIGNALING",
author = "Yuhang Zhang and Philip Tomann and Thomas Andl and Gallant, {Natalie M.} and Joerg Huelsken and Boris Jerchow and Walter Birchmeier and Ralf Paus and Stefano Piccolo and Mikkola, {Marja L.} and Morrisey, {Edward E.} and Overbeek, {Paul A.} and Claus Scheidereit and Millar, {Sarah E.} and Ruth Schmidt-Ullrich",
note = "R01-AR47709-09, AR, NIAMS NIH HHS, United StatesR01-DE015342, DE, NIDCR NIH HHS, United States",
year = "2009",
month = jul,
day = "21",
doi = "10.1016/j.devcel.2009.05.011",
language = "English",
volume = "17",
pages = "49--61",
journal = "Developmental cell",
issn = "1534-5807",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Reciprocal Requirements for EDA/EDAR/NF-κB and Wnt/β-Catenin Signaling Pathways in Hair Follicle Induction

AU - Zhang, Yuhang

AU - Tomann, Philip

AU - Andl, Thomas

AU - Gallant, Natalie M.

AU - Huelsken, Joerg

AU - Jerchow, Boris

AU - Birchmeier, Walter

AU - Paus, Ralf

AU - Piccolo, Stefano

AU - Mikkola, Marja L.

AU - Morrisey, Edward E.

AU - Overbeek, Paul A.

AU - Scheidereit, Claus

AU - Millar, Sarah E.

AU - Schmidt-Ullrich, Ruth

N1 - R01-AR47709-09, AR, NIAMS NIH HHS, United StatesR01-DE015342, DE, NIDCR NIH HHS, United States

PY - 2009/7/21

Y1 - 2009/7/21

N2 - Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/β-catenin signaling requires epithelial β-catenin activity. We find that Wnt/β-catenin signaling is absolutely required for NF-κB activation, and that Edar is a direct Wnt target gene. Wnt/β-catenin signaling is initially activated independently of EDA/EDAR/NF-κB activity in primary hair follicle primordia. However, Eda/Edar/NF-κB signaling is required to refine the pattern of Wnt/β-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-κB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-κB target. These data reveal a complex interplay and interdependence of Wnt/β-catenin and EDA/EDAR/NF-κB signaling pathways in initiation and maintenance of primary hair follicle placodes. © 2009 Elsevier Inc. All rights reserved.

AB - Wnt/β-catenin and NF-κB signaling mechanisms provide central controls in development and disease, but how these pathways intersect is unclear. Using hair follicle induction as a model system, we show that patterning of dermal Wnt/β-catenin signaling requires epithelial β-catenin activity. We find that Wnt/β-catenin signaling is absolutely required for NF-κB activation, and that Edar is a direct Wnt target gene. Wnt/β-catenin signaling is initially activated independently of EDA/EDAR/NF-κB activity in primary hair follicle primordia. However, Eda/Edar/NF-κB signaling is required to refine the pattern of Wnt/β-catenin activity, and to maintain this activity at later stages of placode development. We show that maintenance of localized expression of Wnt10b and Wnt10a requires NF-κB signaling, providing a molecular explanation for the latter observation, and identify Wnt10b as a direct NF-κB target. These data reveal a complex interplay and interdependence of Wnt/β-catenin and EDA/EDAR/NF-κB signaling pathways in initiation and maintenance of primary hair follicle placodes. © 2009 Elsevier Inc. All rights reserved.

KW - DEVBIO

KW - SIGNALING

U2 - 10.1016/j.devcel.2009.05.011

DO - 10.1016/j.devcel.2009.05.011

M3 - Article

C2 - 19619491

VL - 17

SP - 49

EP - 61

JO - Developmental cell

JF - Developmental cell

SN - 1534-5807

IS - 1

ER -