The incremental benefits of obtaining higher levels of skin clearance for patients with psoriasis have been established across several patient reported outcomes (PROs). Patients who obtain clear or almost clear skin are more likely to report no impact of psoriasis on health-related quality of life (HRQoL) and other symptom measures. While the benefits of obtaining higher skin clearance have been reported with different therapeutic agents, the question of whether the benefits of such high levels of response may be offset by an increased risk for adverse outcomes has not been fully explored with biologics. This article is protected by copyright. All rights reserved.