Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis

Research output: Contribution to journalArticle

  • External authors:
  • John W Pickering
  • Martin P Than
  • Louise Cullen
  • Sally Aldous
  • Ewoud Ter Avest
  • Edward W Carlton
  • Paul Collinson
  • Anne Marie Dupuy
  • Ulf Ekelund
  • Kai M Eggers
  • Christopher M Florkowski
  • Yonathan Freund
  • Peter George
  • Steve Goodacre
  • Jaimi H Greenslade
  • Allan S Jaffe
  • Sarah J Lord
  • Arash Mokhtari
  • Christian Mueller
  • Sebbane Mustapha
  • William Parsonage
  • W Frank Peacock
  • Christopher Pemberton
  • A Mark Richards
  • Juan Sanchis
  • Lukas P Staub
  • Richard Troughton
  • Raphael Twerenbold
  • Karin Wildi
  • Joanna Young


Background: High-sensitivity assays for cardiac troponin T (hs-cTnT) are sometimes used to rapidly rule out acute myocardial infarction (AMI).

Purpose: To estimate the ability of a single hs-cTnT concentration below the limit of detection (<0.005 µg/L) and a nonischemic electrocardiogram (ECG) to rule out AMI in adults presenting to the emergency department (ED) with chest pain.

Data Sources: EMBASE and MEDLINE without language restrictions (1 January 2008 to 14 December 2016).

Study Selection: Cohort studies involving adults presenting to the ED with possible acute coronary syndrome in whom an ECG and hs-cTnT measurements were obtained and AMI outcomes adjudicated during initial hospitalization.

Data Extraction: Investigators of studies provided data on the number of low-risk patients (no new ischemia on ECG and hs-cTnT measurements <0.005 µg/L) and the number who had AMI during hospitalization (primary outcome) or a major adverse cardiac event (MACE) or death within 30 days (secondary outcomes), by risk classification (low or not low risk). Two independent epidemiologists rated risk of bias of studies.

Data Synthesis: Of 9241 patients in 11 cohort studies, 2825 (30.6%) were classified as low risk. Fourteen (0.5%) low-risk patients had AMI. Sensitivity of the risk classification for AMI ranged from 87.5% to 100% in individual studies. Pooled estimated sensitivity was 98.7% (95% CI, 96.6% to 99.5%). Sensitivity for 30-day MACEs ranged from 87.9% to 100%; pooled sensitivity was 98.0% (CI, 94.7% to 99.3%). No low-risk patients died.

Limitation: Few studies, variation in timing and methods of reference standard troponin tests, and heterogeneity of risk and prevalence of AMI across studies.

Conclusion: A single hs-cTnT concentration below the limit of detection in combination with a nonischemic ECG may successfully rule out AMI in patients presenting to EDs with possible emergency acute coronary syndrome.

Primary Funding Source: Emergency Care Foundation.

Bibliographical metadata

Original languageEnglish
Pages (from-to)715-724
Number of pages10
JournalAnnals of Internal Medicine
Issue number10
Publication statusPublished - 16 May 2017

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