Radiosynthesis and reactivity of N-[11C]methyl carbamoylimidazole

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Abstract

N-Methyl carbamoylimidazole is a safe and practical alternative to methyl isocyanate for carbamoylation reactions. We have developed a new chemical route for its synthesis from methyl iodide and applied this to the synthesis of N-[11C]methyl carbamoylimidazole as a new [11C]synthon to radiolabel biomolecules for PET imaging research. N-[11C]methyl carbamoylimidazole was prepared from [11C]methyl iodide in 70–74% radiochemical yield (decay corrected) and can be used in situ for further reaction without purification. The reactivity of N-[11C]methyl carbamoylimidazole was demonstrated in a series of [11C]carbamoylation reactions.

Bibliographical metadata

Original languageEnglish
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume317
Issue number2
Early online date19 Jun 2018
DOIs
Publication statusPublished - Aug 2018