Radiogenomics and radiotherapy response modeling.Citation formats
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Radiogenomics and radiotherapy response modeling. / El Naqa, Issam ; West, Catharine.
In: Physics in Medicine and Biology, Vol. 62, No. 16, 01.08.2017, p. R179-R206.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Radiogenomics and radiotherapy response modeling.
AU - El Naqa, Issam
AU - West, Catharine
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Advances in patient-specific information and biotechnology have contributed to a new era of computational medicine. Radiogenomics has emerged as a new field that investigates the role of genetics in treatment response to radiation therapy. Radiation oncology is currently attempting to embrace these recent advances and add to its rich history by maintaining its prominent role as a quantitative leader in oncologic response modeling. Here, we provide an overview of radiogenomics starting with genotyping, data aggregation, and application of different modeling approaches based on modifying traditional radiobiological methods or application of advanced machine learning techniques. We highlight the current status and potential for this new field to reshape the landscape of outcome modeling in radiotherapy and drive future advances in computational oncology.
AB - Advances in patient-specific information and biotechnology have contributed to a new era of computational medicine. Radiogenomics has emerged as a new field that investigates the role of genetics in treatment response to radiation therapy. Radiation oncology is currently attempting to embrace these recent advances and add to its rich history by maintaining its prominent role as a quantitative leader in oncologic response modeling. Here, we provide an overview of radiogenomics starting with genotyping, data aggregation, and application of different modeling approaches based on modifying traditional radiobiological methods or application of advanced machine learning techniques. We highlight the current status and potential for this new field to reshape the landscape of outcome modeling in radiotherapy and drive future advances in computational oncology.
U2 - 10.1088/1361-6560/aa7c55
DO - 10.1088/1361-6560/aa7c55
M3 - Article
VL - 62
SP - R179-R206
JO - Physics in Medicine and Biology
JF - Physics in Medicine and Biology
SN - 0031-9155
IS - 16
ER -