Radical Anions from Urea-type Carbonyls: Radical Cyclizations and Cyclization Cascades

Research output: Contribution to journalArticle

Abstract

Radical anions generated from urea carbonyls by reductive electron transfer are exploited in carbon-carbon bond formation. New radical cyclizations of urea radical anions deliver complex nitrogen heterocycles and, depending upon the proton
source used in the reactions, a chemoselective switch between reaction pathways can deliver two heterobicyclic scaffolds. A computational study has been used to investigate the selectivity of the urea radical processes. Furthermore, radical cyclization cascades involving urea radical anions deliver unusual spirocyclic
aminal architectures.

Bibliographical metadata

Original languageEnglish
Pages (from-to)4995-4999
Number of pages5
JournalAngewandte Chemie
Volume57
Issue number18
Early online date1 Mar 2018
DOIs
Publication statusPublished - 17 Apr 2018

Related information