Radiation and the genome: From risks to opportunities for therapeutic exploitation

Research output: Contribution to journalArticle

Abstract

On 1 December 2009, the Radiation and Cancer Biology Committee of the British Institute of Radiology (BIR) held a one-day conference on the theme of radiation and the genome. Talks covered genomic instability (its importance for radiation-induced carcinogenesis and potential for exploitation in the development of novel chemoradiotherapy combinations) and the prospects of exploiting knowledge of the genome to understand how individual genetic variation can impact on a patient's likelihood of developing toxicity following radiotherapy. The meeting also provided an overview of stem cell biology and its relevance for radiotherapy in terms of both tumour (somatic) and normal tissue (germline) sensitivity to radiation. Moreover, the possibility of manipulating stem cells to reduce radiation-induced normal tissue damage was considered. © 2010 The British Institute of Radiology.

Bibliographical metadata

Original languageEnglish
Pages (from-to)635-637
Number of pages2
JournalBritish Journal of Radiology
Volume83
Issue number992
DOIs
Publication statusPublished - Aug 2010