β-pyrophosphate: A potential biomaterial for dental applications

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • S. Strafford
  • O. Posada-Estefan
  • C.L. Thomson
  • S.A. Hussain
  • T.J. Edwards
  • M. Malinowski
  • Nicole S. Hondow
  • N.K. Metzger
  • C.T.A. Brown
  • M.N. Routledge
  • A.P. Brown
  • M.S. Duggal
  • Animesh Jha

Abstract

Tooth hypersensitivity is a growing problem affecting both the young and ageing population worldwide. Since an effective and permanent solution is not yet available, we propose a new methodology for the restoration of dental enamel using femtosecond lasers and novel calcium phosphate biomaterials. During this procedure the irradiated mineral transforms into a densified layer of acid resistant iron doped β-pyrophosphate, bonded with the surface of eroded enamel. Our aim therefore is to evaluate this densified mineral as a potential replacement material for dental hard tissue. To this end, we have tested the hardness of β-pyrophosphate pellets (sintered at 1000 °C) and its mineral precursor (brushite), the wear rate during simulated tooth-brushing trials and the cytocompatibility of these minerals in powder form. It was found that the hardness of the β-pyrophosphate pellets is comparable with that of dental enamel and significantly higher than dentine while, the brushing trials prove that the wear rate of β-pyrophosphate is much slower than that of natural enamel. Finally, cytotoxicity and genotoxicity tests suggest that iron doped β-pyrophosphate is cytocompatible and therefore could be used in dental applications. Taken together and with the previously reported results on laser irradiation of these materials we conclude that iron doped β-pyrophosphate may be a promising material for restoring acid eroded and worn enamel.

Bibliographical metadata

Original languageEnglish
JournalMaterials Science and Engineering C
Early online date24 Feb 2017
DOIs
Publication statusPublished - 2017