Psoriasis and Mental Health Workshop Report: Exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Nehal N Mehta
  • Francesca Sampogna
  • Chris Bundy
  • Alexa B Kimball
  • Peter van de Kerkhof
  • Fernando Valenzuela
  • Joelle M. van der Walt
  • Tsion Aberra
  • Lluis Puig

Abstract

Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL-23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, “Psoriasis and Mental Health”, in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention.

Bibliographical metadata

Original languageEnglish
Article numberadv00020
Pages (from-to)1-8
Number of pages8
JournalActa Dermato-Venereologica
Volume100
Issue number1
Early online date19 Nov 2019
DOIs
Publication statusPublished - 2020