Protein surface recognition and proteomimetics: Mimics of protein surface structure and function

Research output: Contribution to journalArticle

Abstract

Due to their key roles in a number of biological processes, protein-protein interactions are attractive and important targets, typically involving areas greater than 6 nm2. The disruption of such interactions remains a challenging feat but, in recent years, there has been considerable progress in the design of proteomimetics: molecules that mimic the structure and function of extended regions of protein surfaces. In particular, porphyrins, calixarenes, α-helical mimetics and small molecules have successfully modulated significant protein-protein interactions, including those involved in cancer and HIV. © 2005 Elsevier Ltd. All rights reserved.

Bibliographical metadata

Original languageEnglish
Pages (from-to)632-638
Number of pages6
JournalCurrent Opinion in Chemical Biology
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 2005