Prognostic value of hypoxia-associated markers in advanced larynx and hypopharynx squamous cell carcinoma.

Research output: Contribution to journalArticlepeer-review

  • Authors:
  • Jonathan M Bernstein
  • Timothy D Andrews
  • Nick J Slevin
  • Catharine M L West
  • Jarrod J Homer


OBJECTIVES/HYPOTHESIS: To determine the prognostic value of hypoxia-associated markers carbonic anhydrase-9 (CA-9) and hypoxia-inducible factor-1α (HIF-1α) in advanced larynx and hypopharynx squamous cell carcinoma (SCCa) treated by organ preservation strategies. STUDY DESIGN: Retrospective cohort study. METHODS: Pretreatment CA-9 and HIF-1α expression, clinicopathologic data, and tumor volume were analyzed in a series of 114 patients with T3-4 SCCa larynx or hypopharynx treated by (chemo)radiation. RESULTS: Adverse prognostic factors for locoregional control were T4 classification (P = 0.008), and for disease-specific survival were CA-9 positivity (P = 0.039), T4 classification (P = 0.001), larger tumor volume (P = 0.004), N1-3 classification (P = 0.002), and pretreatment hemoglobin 

Bibliographical metadata

Original languageEnglish
JournalThe Laryngoscope
Issue number1
Publication statusPublished - Jan 2015