Primary care-based screening for cardiovascular risk factors in patients with psoriasisCitation formats

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Primary care-based screening for cardiovascular risk factors in patients with psoriasis. / Rutter, M K; Kane, K; Lunt, M; Cordingley, L; Littlewood, Alison; Young, H S; Chew-Graham, C A; Hilton, R; Symmons, D P M; Griffiths, C E M.

In: The British journal of dermatology, Vol. 175, No. 2, 18.08.2016, p. 348-356.

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@article{ddebb0050d784f6ca5ec5693f7de4c2d,
title = "Primary care-based screening for cardiovascular risk factors in patients with psoriasis",
abstract = "BACKGROUND: Studies assessing cardiovascular disease (CVD) risk factors in patients with psoriasis have been limited by selection bias, inappropriate controls or a reliance on data collected for clinical reasons.OBJECTIVES: To investigate whether screening for CVD risk factors in patients with psoriasis in primary care augments the known prevalence of CVD risk factors in a cross-sectional study.METHODS: Patients listed as having psoriasis in primary care were recruited, screened and risk assessed by QRISK2.RESULTS: In total, 287 patients attended (mean age 53 years, 57% women, 94% white British, 22% severe disease, 33% self-reported psoriatic arthritis). The proportion with known and screen-detected (previously unknown) risk factors was as follows: hypertension 35% known and 13% screen-detected; hypercholesterolaemia 32% and 37%; diabetes 6·6% and 3·1% and chronic kidney disease 1·1% and 4·5%. At least one screen-detected risk factor was found in 48% and two or more risk factors were found in 21% of patients. One in three patients (37%) not previously known to be at high risk were found to have a high (> 10%) 10-year CVD risk. Among the participants receiving treatment for known CVD risk factors, nearly half had suboptimal levels for blood pressure (46%) and cholesterol (46%).CONCLUSIONS: Cardiovascular risk factor screening of primary care-based adults with psoriasis identified a high proportion of patients (i) at high CVD risk, (ii) with screen-detected risk factors and (iii) with suboptimally managed known risk factors. These findings need to be considered alongside reports that detected limited responses of clinicians to identified risk factors before universal CVD screening can be recommended.",
author = "Rutter, {M K} and K Kane and M Lunt and L Cordingley and Alison Littlewood and Young, {H S} and Chew-Graham, {C A} and R Hilton and Symmons, {D P M} and Griffiths, {C E M}",
note = "{\textcopyright} 2016 British Association of Dermatologists.",
year = "2016",
month = aug,
day = "18",
doi = "10.1111/bjd.14557",
language = "English",
volume = "175",
pages = "348--356",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "John Wiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Primary care-based screening for cardiovascular risk factors in patients with psoriasis

AU - Rutter, M K

AU - Kane, K

AU - Lunt, M

AU - Cordingley, L

AU - Littlewood, Alison

AU - Young, H S

AU - Chew-Graham, C A

AU - Hilton, R

AU - Symmons, D P M

AU - Griffiths, C E M

N1 - © 2016 British Association of Dermatologists.

PY - 2016/8/18

Y1 - 2016/8/18

N2 - BACKGROUND: Studies assessing cardiovascular disease (CVD) risk factors in patients with psoriasis have been limited by selection bias, inappropriate controls or a reliance on data collected for clinical reasons.OBJECTIVES: To investigate whether screening for CVD risk factors in patients with psoriasis in primary care augments the known prevalence of CVD risk factors in a cross-sectional study.METHODS: Patients listed as having psoriasis in primary care were recruited, screened and risk assessed by QRISK2.RESULTS: In total, 287 patients attended (mean age 53 years, 57% women, 94% white British, 22% severe disease, 33% self-reported psoriatic arthritis). The proportion with known and screen-detected (previously unknown) risk factors was as follows: hypertension 35% known and 13% screen-detected; hypercholesterolaemia 32% and 37%; diabetes 6·6% and 3·1% and chronic kidney disease 1·1% and 4·5%. At least one screen-detected risk factor was found in 48% and two or more risk factors were found in 21% of patients. One in three patients (37%) not previously known to be at high risk were found to have a high (> 10%) 10-year CVD risk. Among the participants receiving treatment for known CVD risk factors, nearly half had suboptimal levels for blood pressure (46%) and cholesterol (46%).CONCLUSIONS: Cardiovascular risk factor screening of primary care-based adults with psoriasis identified a high proportion of patients (i) at high CVD risk, (ii) with screen-detected risk factors and (iii) with suboptimally managed known risk factors. These findings need to be considered alongside reports that detected limited responses of clinicians to identified risk factors before universal CVD screening can be recommended.

AB - BACKGROUND: Studies assessing cardiovascular disease (CVD) risk factors in patients with psoriasis have been limited by selection bias, inappropriate controls or a reliance on data collected for clinical reasons.OBJECTIVES: To investigate whether screening for CVD risk factors in patients with psoriasis in primary care augments the known prevalence of CVD risk factors in a cross-sectional study.METHODS: Patients listed as having psoriasis in primary care were recruited, screened and risk assessed by QRISK2.RESULTS: In total, 287 patients attended (mean age 53 years, 57% women, 94% white British, 22% severe disease, 33% self-reported psoriatic arthritis). The proportion with known and screen-detected (previously unknown) risk factors was as follows: hypertension 35% known and 13% screen-detected; hypercholesterolaemia 32% and 37%; diabetes 6·6% and 3·1% and chronic kidney disease 1·1% and 4·5%. At least one screen-detected risk factor was found in 48% and two or more risk factors were found in 21% of patients. One in three patients (37%) not previously known to be at high risk were found to have a high (> 10%) 10-year CVD risk. Among the participants receiving treatment for known CVD risk factors, nearly half had suboptimal levels for blood pressure (46%) and cholesterol (46%).CONCLUSIONS: Cardiovascular risk factor screening of primary care-based adults with psoriasis identified a high proportion of patients (i) at high CVD risk, (ii) with screen-detected risk factors and (iii) with suboptimally managed known risk factors. These findings need to be considered alongside reports that detected limited responses of clinicians to identified risk factors before universal CVD screening can be recommended.

U2 - 10.1111/bjd.14557

DO - 10.1111/bjd.14557

M3 - Article

C2 - 26990294

VL - 175

SP - 348

EP - 356

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 2

ER -