Preservation of circadian rhythms by the protein folding chaperone, BiPCitation formats

  • External authors:
  • Nissrin Alachkar
  • Ben Calverley
  • Richa Garva
  • Peter Arvan

Standard

Preservation of circadian rhythms by the protein folding chaperone, BiP. / Pickard, Adam; Chang, Joan; Alachkar, Nissrin; Calverley, Ben; Garva, Richa; Arvan, Peter; Meng, Qing-Jun; Kadler, Karl.

In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30.05.2019.

Research output: Contribution to journalArticlepeer-review

Harvard

Pickard, A, Chang, J, Alachkar, N, Calverley, B, Garva, R, Arvan, P, Meng, Q-J & Kadler, K 2019, 'Preservation of circadian rhythms by the protein folding chaperone, BiP', The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201802366RR

APA

Pickard, A., Chang, J., Alachkar, N., Calverley, B., Garva, R., Arvan, P., Meng, Q-J., & Kadler, K. (2019). Preservation of circadian rhythms by the protein folding chaperone, BiP. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. https://doi.org/10.1096/fj.201802366RR

Vancouver

Pickard A, Chang J, Alachkar N, Calverley B, Garva R, Arvan P et al. Preservation of circadian rhythms by the protein folding chaperone, BiP. The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019 May 30. https://doi.org/10.1096/fj.201802366RR

Author

Pickard, Adam ; Chang, Joan ; Alachkar, Nissrin ; Calverley, Ben ; Garva, Richa ; Arvan, Peter ; Meng, Qing-Jun ; Kadler, Karl. / Preservation of circadian rhythms by the protein folding chaperone, BiP. In: The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2019.

Bibtex

@article{38507d7fc4ff4284b4d2759d4f595e7e,
title = "Preservation of circadian rhythms by the protein folding chaperone, BiP",
abstract = "Dysregulation of collagen synthesis is associated with disease progression in cancer and fibrosis. Collagen synthesis is coordinated with the circadian clock, which curiously in cancer cells, is deregulated by ER stress. We hypothesized interplay between circadian rhythm, collagen synthesis and ER stress in normal cells. Here we show that fibroblasts with ER stress lack circadian rhythms in gene expression upon clock-synchronizing time cues. Overexpression of BiP or treatment with chemical chaperones strengthens the oscillation amplitude of circadian rhythms. The significance of these findings was explored in tendon, where we showed that BiP expression is ramped pre-emptively prior to a surge in collagen synthesis at night, thereby preventing protein mis-folding and ER stress. In turn, this forestalls activation of the unfolded protein response in order for circadian rhythms to be maintained. Thus, targeting ER stress could be used to modulate circadian rhythm and restore collagen homeostasis in disease.",
author = "Adam Pickard and Joan Chang and Nissrin Alachkar and Ben Calverley and Richa Garva and Peter Arvan and Qing-Jun Meng and Karl Kadler",
year = "2019",
month = may,
day = "30",
doi = "10.1096/fj.201802366RR",
language = "English",
journal = "The FASEB journal : official publication of the Federation of American Societies for Experimental Biology",
issn = "0892-6638",
publisher = "Federation of American Societies for Experimental Biology",

}

RIS

TY - JOUR

T1 - Preservation of circadian rhythms by the protein folding chaperone, BiP

AU - Pickard, Adam

AU - Chang, Joan

AU - Alachkar, Nissrin

AU - Calverley, Ben

AU - Garva, Richa

AU - Arvan, Peter

AU - Meng, Qing-Jun

AU - Kadler, Karl

PY - 2019/5/30

Y1 - 2019/5/30

N2 - Dysregulation of collagen synthesis is associated with disease progression in cancer and fibrosis. Collagen synthesis is coordinated with the circadian clock, which curiously in cancer cells, is deregulated by ER stress. We hypothesized interplay between circadian rhythm, collagen synthesis and ER stress in normal cells. Here we show that fibroblasts with ER stress lack circadian rhythms in gene expression upon clock-synchronizing time cues. Overexpression of BiP or treatment with chemical chaperones strengthens the oscillation amplitude of circadian rhythms. The significance of these findings was explored in tendon, where we showed that BiP expression is ramped pre-emptively prior to a surge in collagen synthesis at night, thereby preventing protein mis-folding and ER stress. In turn, this forestalls activation of the unfolded protein response in order for circadian rhythms to be maintained. Thus, targeting ER stress could be used to modulate circadian rhythm and restore collagen homeostasis in disease.

AB - Dysregulation of collagen synthesis is associated with disease progression in cancer and fibrosis. Collagen synthesis is coordinated with the circadian clock, which curiously in cancer cells, is deregulated by ER stress. We hypothesized interplay between circadian rhythm, collagen synthesis and ER stress in normal cells. Here we show that fibroblasts with ER stress lack circadian rhythms in gene expression upon clock-synchronizing time cues. Overexpression of BiP or treatment with chemical chaperones strengthens the oscillation amplitude of circadian rhythms. The significance of these findings was explored in tendon, where we showed that BiP expression is ramped pre-emptively prior to a surge in collagen synthesis at night, thereby preventing protein mis-folding and ER stress. In turn, this forestalls activation of the unfolded protein response in order for circadian rhythms to be maintained. Thus, targeting ER stress could be used to modulate circadian rhythm and restore collagen homeostasis in disease.

U2 - 10.1096/fj.201802366RR

DO - 10.1096/fj.201802366RR

M3 - Article

JO - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

JF - The FASEB journal : official publication of the Federation of American Societies for Experimental Biology

SN - 0892-6638

ER -