Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid TumorsCitation formats

  • External authors:
  • John C. Waterton
  • Yvonne Watson
  • Giovanni A. Buonaccorsi
  • Sue Cheung
  • David L. Buckley
  • Deirdre M. McGrath
  • Susan E. Davidson
  • Caleb Roberts
  • Samantha J. Mills
  • Claire L. Mitchell
  • Lynn Hope
  • N. Chan Ton
  • Alan Jackson

Standard

Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors. / O'Connor, James P B; Naish, Josephine H.; Parker, Geoff J M; Waterton, John C.; Watson, Yvonne; Jayson, Gordon C.; Buonaccorsi, Giovanni A.; Cheung, Sue; Buckley, David L.; McGrath, Deirdre M.; West, Catharine M L; Davidson, Susan E.; Roberts, Caleb; Mills, Samantha J.; Mitchell, Claire L.; Hope, Lynn; Ton, N. Chan; Jackson, Alan.

In: International Journal of Radiation: Oncology - Biology - Physics, Vol. 75, No. 4, 6, 15.11.2009, p. 1209-1215.

Research output: Contribution to journal › Article › peer-review

Harvard

O'Connor, JPB, Naish, JH, Parker, GJM, Waterton, JC, Watson, Y, Jayson, GC, Buonaccorsi, GA, Cheung, S, Buckley, DL, McGrath, DM, West, CML, Davidson, SE, Roberts, C, Mills, SJ, Mitchell, CL, Hope, L, Ton, NC & Jackson, A 2009, 'Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors', International Journal of Radiation: Oncology - Biology - Physics, vol. 75, no. 4, 6, pp. 1209-1215. https://doi.org/10.1016/j.ijrobp.2008.12.040

APA

O'Connor, J. P. B., Naish, J. H., Parker, G. J. M., Waterton, J. C., Watson, Y., Jayson, G. C., Buonaccorsi, G. A., Cheung, S., Buckley, D. L., McGrath, D. M., West, C. M. L., Davidson, S. E., Roberts, C., Mills, S. J., Mitchell, C. L., Hope, L., Ton, N. C., & Jackson, A. (2009). Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors. International Journal of Radiation: Oncology - Biology - Physics, 75(4), 1209-1215. [6]. https://doi.org/10.1016/j.ijrobp.2008.12.040

Vancouver

O'Connor JPB, Naish JH, Parker GJM, Waterton JC, Watson Y, Jayson GC et al. Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors. International Journal of Radiation: Oncology - Biology - Physics. 2009 Nov 15;75(4):1209-1215. 6. https://doi.org/10.1016/j.ijrobp.2008.12.040

Author

O'Connor, James P B ; Naish, Josephine H. ; Parker, Geoff J M ; Waterton, John C. ; Watson, Yvonne ; Jayson, Gordon C. ; Buonaccorsi, Giovanni A. ; Cheung, Sue ; Buckley, David L. ; McGrath, Deirdre M. ; West, Catharine M L ; Davidson, Susan E. ; Roberts, Caleb ; Mills, Samantha J. ; Mitchell, Claire L. ; Hope, Lynn ; Ton, N. Chan ; Jackson, Alan. / Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors. In: International Journal of Radiation: Oncology - Biology - Physics. 2009 ; Vol. 75, No. 4. pp. 1209-1215.

Bibtex

@article{2af19f23a06f467e9075aa9dc60f111d,
title = "Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors",
abstract = "Purpose: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R1). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. Methods and materials: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R1 while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced ΔR1. Results: ΔR1 showed significant increases of 0.021 to 0.058 s-1 in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the ΔR1 curve (consistent with minimal increase in oxygen concentration). Conclusions: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration. {\textcopyright} 2009 Elsevier Inc. All rights reserved.",
keywords = "Biomarker, Longitudinal relaxation rate (R1), MRI, Neoplasm, Oxygen",
author = "O'Connor, {James P B} and Naish, {Josephine H.} and Parker, {Geoff J M} and Waterton, {John C.} and Yvonne Watson and Jayson, {Gordon C.} and Buonaccorsi, {Giovanni A.} and Sue Cheung and Buckley, {David L.} and McGrath, {Deirdre M.} and West, {Catharine M L} and Davidson, {Susan E.} and Caleb Roberts and Mills, {Samantha J.} and Mitchell, {Claire L.} and Lynn Hope and Ton, {N. Chan} and Alan Jackson",
note = "O'Connor J.P.B. Naish J.H. Parker G.J.M. Waterton J.C. Watson Y. Jayson G.C. Buonaccorsi G.A. Cheung S. Buckley D.L. McGrath D.M. West C.M.L. Davidson S.E. Roberts C. Mills S.J. Mitchell C.L. Hope L. Ton N.C. Jackson A. International Journal of Radiation Oncology Biology Physics. 75 (4) (pp 1209-1215), 2009. Date of Publication Journal: Article",
year = "2009",
month = nov,
day = "15",
doi = "10.1016/j.ijrobp.2008.12.040",
language = "English",
volume = "75",
pages = "1209--1215",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "4",

}

RIS

TY - JOUR

T1 - Preliminary Study of Oxygen-Enhanced Longitudinal Relaxation in MRI: A Potential Novel Biomarker of Oxygenation Changes in Solid Tumors

AU - O'Connor, James P B

AU - Naish, Josephine H.

AU - Parker, Geoff J M

AU - Waterton, John C.

AU - Watson, Yvonne

AU - Jayson, Gordon C.

AU - Buonaccorsi, Giovanni A.

AU - Cheung, Sue

AU - Buckley, David L.

AU - McGrath, Deirdre M.

AU - West, Catharine M L

AU - Davidson, Susan E.

AU - Roberts, Caleb

AU - Mills, Samantha J.

AU - Mitchell, Claire L.

AU - Hope, Lynn

AU - Ton, N. Chan

AU - Jackson, Alan

N1 - O'Connor J.P.B. Naish J.H. Parker G.J.M. Waterton J.C. Watson Y. Jayson G.C. Buonaccorsi G.A. Cheung S. Buckley D.L. McGrath D.M. West C.M.L. Davidson S.E. Roberts C. Mills S.J. Mitchell C.L. Hope L. Ton N.C. Jackson A. International Journal of Radiation Oncology Biology Physics. 75 (4) (pp 1209-1215), 2009. Date of Publication Journal: Article

PY - 2009/11/15

Y1 - 2009/11/15

N2 - Purpose: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R1). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. Methods and materials: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R1 while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced ΔR1. Results: ΔR1 showed significant increases of 0.021 to 0.058 s-1 in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the ΔR1 curve (consistent with minimal increase in oxygen concentration). Conclusions: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration. © 2009 Elsevier Inc. All rights reserved.

AB - Purpose: There is considerable interest in developing non-invasive methods of mapping tumor hypoxia. Changes in tissue oxygen concentration produce proportional changes in the magnetic resonance imaging (MRI) longitudinal relaxation rate (R1). This technique has been used previously to evaluate oxygen delivery to healthy tissues and is distinct from blood oxygenation level-dependent (BOLD) imaging. Here we report application of this method to detect alteration in tumor oxygenation status. Methods and materials: Ten patients with advanced cancer of the abdomen and pelvis underwent serial measurement of tumor R1 while breathing medical air (21% oxygen) followed by 100% oxygen (oxygen-enhanced MRI). Gadolinium-based dynamic contrast-enhanced MRI was then performed to compare the spatial distribution of perfusion with that of oxygen-induced ΔR1. Results: ΔR1 showed significant increases of 0.021 to 0.058 s-1 in eight patients with either locally recurrent tumor from cervical and hepatocellular carcinomas or metastases from ovarian and colorectal carcinomas. In general, there was congruency between perfusion and oxygen concentration. However, regional mismatch was observed in some tumor cores. Here, moderate gadolinium uptake (consistent with moderate perfusion) was associated with low area under the ΔR1 curve (consistent with minimal increase in oxygen concentration). Conclusions: These results provide evidence that oxygen-enhanced longitudinal relaxation can monitor changes in tumor oxygen concentration. The technique shows promise in identifying hypoxic regions within tumors and may enable spatial mapping of change in tumor oxygen concentration. © 2009 Elsevier Inc. All rights reserved.

KW - Biomarker

KW - Longitudinal relaxation rate (R1)

KW - MRI

KW - Neoplasm

KW - Oxygen

U2 - 10.1016/j.ijrobp.2008.12.040

DO - 10.1016/j.ijrobp.2008.12.040

M3 - Article

C2 - 19327904

VL - 75

SP - 1209

EP - 1215

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 4

M1 - 6

ER -