Predictors of onset of depression and anxiety in the year after diagnosis of breast cancer

Research output: Contribution to journalArticle

  • Authors:
  • J. Hill
  • C. Holcombe
  • L. Clark
  • M. R K Boothby
  • A. Hincks
  • And 3 others
  • External authors:
  • J. Fisher
  • S. Tufail
  • P. Salmon


Background Depression and anxiety are common after diagnosis of breast cancer. We examined to what extent these are recurrences of previous disorder and, controlling for this, whether shame, self-blame and low social support after diagnosis predicted onset of depression and anxiety subsequently.Method Women with primary breast cancer who had been treated surgically self-reported shame, self-blame, social support and emotional distress post-operatively. Psychiatric interview 12 months later identified those with adult lifetime episodes of major depression (MD) or generalized anxiety disorder (GAD) before diagnosis and onset over the subsequent year. Statistical analysis examined predictors of each disorder in that year.Results Of the patients, two-thirds with episodes of MD and 40% with episodes of GAD during the year after diagnosis were experiencing recurrence of previous disorder. Although low social support, self-blame and shame were each associated with both MD and GAD after diagnosis, they did not mediate the relationship of disorder after diagnosis with previous disorder. Low social support, but not shame or self-blame, predicted recurrence after controlling for previous disorder.Conclusions Anxiety and depression during the first year after diagnosis of breast cancer are often the recurrence of previous disorder. In predicting disorder following diagnosis, self-blame and shame are merely markers of previous disorder. Low social support is an independent predictor and therefore may have a causal role. © 2011 Cambridge University Press.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1429-1436
Number of pages7
JournalPsychological Medicine
Issue number7
Publication statusPublished - Jul 2011