Potential roles in rhinitis for protease and other enzymatic activities of allergens

Research output: Contribution to journalArticle

  • Authors:
  • Nita Sehgal
  • Adnan Custovic
  • Ashley Woodcock

Abstract

Exposure to airborne pollen, fungal allergens, and dust mite allergens is associated with the development of allergic rhinitis. Biologic function of allergens is considered to be a key determinant for allergenicity, and many clinically important allergens have been shown to possess enzymatic activity. It is proposed that by enabling allergens to breach the integrity of the airway epithelial barrier, proteolytic activity plays an adjuvant pro-allergic role influencing immunogenicity. In this review, current evidence regarding enzymatic activity of aeroallergens is described, and the potential role of aeroallergens in allergic rhinitis is discussed. Copyright © 2005 by Current Science Inc.

Bibliographical metadata

Original languageEnglish
Pages (from-to)221-226
Number of pages5
JournalCurrent allergy and asthma reports
Volume5
Issue number3
Publication statusPublished - May 2005