Population pharmacokinetic and pharmacodynamic modelling of the antimalarial chemotherapy chlorproguanil/dapsone

Research output: Contribution to journalArticle

  • External authors:
  • Julie A. Simpson
  • Dyfrig Hughes
  • Christine Manyando
  • Kalifa Bojang
  • Peter Winstanley
  • Geoffrey Edwards
  • William A. Watkins
  • Steve Ward

Abstract

Aims: To determine the population pharmacokinetics of chlorproguanil, dapsone and the active metabolite of chlorproguanil, chlorcycloguanil; and to estimate the duration of parasitocidal activity for chlorpoguanil/dapsone against Plasmodium falciparum isolates of varying sensitivity. Methods: Rich and sparse pharmacokinetic data were collected prospectively from: healthy volunteers (n = 48) and adults (n = 65) and children (n = 68) suffering from P. falciparum malaria. All subjects received 2.0 mg kg-1 of chlorproguanil and 2.5 mg kg-1 of dapsone. Results: The population pharmacokinetic parameter estimates for chlorproguanil were ka = 00.09 h-1 (intersubject variability was 44%), CL/F = 51.53 l h -1 (57%), CLD/F = 54.67 l h-1, V1/F = 234.40 l (50%) and V2/F = 1612.75 l; for dapsone were ka = 00.93 h-1, CL/F = 1.99 l h-1 (72%) and V/F = 76.96 l (48%); and for chlorcycloguanil were CLm/Fm = 3.72 l h-1 kg-1 (67%) and Vm/Fm = 12.76 l kg-1 (64%). For dapsone, CL/F and V/F were both significantly positively correlated with body weight. For a 10-kg child, the mean duration of parasitocidal activity for chlorproguanil/dapsone against the three most susceptible P. falciparum strains was 4.5 days [5th and 95th percentiles 2.4, 7.3] for W282; 5.9 days (3.6, 9.7) for ItG2F6; and 6.1 days (3.7, 10.1) for K39. For an isolate with the ile-164-leu mutation, V1/S, activity ranged from 0.8 days (0.0, 3.3) for a 10-kg child to 1.8 days (0.0, 4.0) for a 60-kg adult. Conclusions: Plasmodium falciparum malaria has no effect on the pharmacokinetic parameters for chlorproguanil, dapsone or chlorcycloguanil. Chlorproguanil/ dapsone will probably prove to be ineffective against parasite strains with the mutation ile-164-leu, were these to become prevalent in Africa. © 2006 Blackwell Publishing Ltd.

Bibliographical metadata

Original languageEnglish
Pages (from-to)289-300
Number of pages11
JournalBritish Journal of Clinical Pharmacology
Volume61
Issue number3
DOIs
Publication statusPublished - Mar 2006