Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivityCitation formats

  • External authors:
  • John S. Hall
  • Rohan Iype
  • Lucile S C Armenoult
  • Janet Taylor
  • Crispin J. Miller
  • Susan Davidson
  • Silvia De Sanjose
  • Xavier Bosch
  • Peter L. Stern

Standard

Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity. / Hall, John S.; Iype, Rohan; Armenoult, Lucile S C; Taylor, Janet; Miller, Crispin J.; Davidson, Susan; De Sanjose, Silvia; Bosch, Xavier; Stern, Peter L.; West, Catharine M L.

In: International Journal of Radiation Oncology Biology Physics, Vol. 85, No. 5, 01.04.2013, p. e223-e229.

Research output: Contribution to journalArticlepeer-review

Harvard

Hall, JS, Iype, R, Armenoult, LSC, Taylor, J, Miller, CJ, Davidson, S, De Sanjose, S, Bosch, X, Stern, PL & West, CML 2013, 'Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity', International Journal of Radiation Oncology Biology Physics, vol. 85, no. 5, pp. e223-e229. https://doi.org/10.1016/j.ijrobp.2012.11.030

APA

Hall, J. S., Iype, R., Armenoult, L. S. C., Taylor, J., Miller, C. J., Davidson, S., De Sanjose, S., Bosch, X., Stern, P. L., & West, C. M. L. (2013). Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity. International Journal of Radiation Oncology Biology Physics, 85(5), e223-e229. https://doi.org/10.1016/j.ijrobp.2012.11.030

Vancouver

Hall JS, Iype R, Armenoult LSC, Taylor J, Miller CJ, Davidson S et al. Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity. International Journal of Radiation Oncology Biology Physics. 2013 Apr 1;85(5):e223-e229. https://doi.org/10.1016/j.ijrobp.2012.11.030

Author

Hall, John S. ; Iype, Rohan ; Armenoult, Lucile S C ; Taylor, Janet ; Miller, Crispin J. ; Davidson, Susan ; De Sanjose, Silvia ; Bosch, Xavier ; Stern, Peter L. ; West, Catharine M L. / Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity. In: International Journal of Radiation Oncology Biology Physics. 2013 ; Vol. 85, No. 5. pp. e223-e229.

Bibtex

@article{13c797c554b248948235285af487d55a,
title = "Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity",
abstract = "Purpose: To investigate the relationship between human papillomavirus (HPV) genotype and outcome after radiation therapy and intrinsic radiosensitivity. Methods and Materials: HPV genotyping was performed on cervix biopsies by polymerase chain reaction using SPF-10 broad-spectrum primers, followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse hybridization line probe assay (LiPA25) (version 1) (n=202). PapilloCheck and quantitative reverse transcription-polymerase chain reaction were used to genotype cervix cancer cell lines (n=16). Local progression-free survival after radiation therapy alone was assessed using log-rank and Cox proportionate hazard analyses. Intrinsic radiosensitivity was measured as surviving fraction at 2 Gy (SF2) using clonogenic assays. Results: Of the 202 tumors, 107 (53.0%) were positive for HPV16, 29 (14.4%) for HPV18, 9 (4.5%) for HPV45, 23 (11.4%) for other HPV genotypes, and 22 (10.9%) were negative; 11 (5.5%) contained multiple genotypes, and 1 tumor was HPV X (0.5%). In 148 patients with outcome data, those with HPVα9-positive tumors had better local progression-free survival compared with α7 patients in univariate (P",
author = "Hall, {John S.} and Rohan Iype and Armenoult, {Lucile S C} and Janet Taylor and Miller, {Crispin J.} and Susan Davidson and {De Sanjose}, Silvia and Xavier Bosch and Stern, {Peter L.} and West, {Catharine M L}",
year = "2013",
month = apr,
day = "1",
doi = "10.1016/j.ijrobp.2012.11.030",
language = "English",
volume = "85",
pages = "e223--e229",
journal = "International Journal of Radiation: Oncology - Biology - Physics",
issn = "0360-3016",
publisher = "Elsevier BV",
number = "5",

}

RIS

TY - JOUR

T1 - Poor prognosis associated with human papillomavirus α7 genotypes in cervical carcinoma cannot be explained by intrinsic radiosensitivity

AU - Hall, John S.

AU - Iype, Rohan

AU - Armenoult, Lucile S C

AU - Taylor, Janet

AU - Miller, Crispin J.

AU - Davidson, Susan

AU - De Sanjose, Silvia

AU - Bosch, Xavier

AU - Stern, Peter L.

AU - West, Catharine M L

PY - 2013/4/1

Y1 - 2013/4/1

N2 - Purpose: To investigate the relationship between human papillomavirus (HPV) genotype and outcome after radiation therapy and intrinsic radiosensitivity. Methods and Materials: HPV genotyping was performed on cervix biopsies by polymerase chain reaction using SPF-10 broad-spectrum primers, followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse hybridization line probe assay (LiPA25) (version 1) (n=202). PapilloCheck and quantitative reverse transcription-polymerase chain reaction were used to genotype cervix cancer cell lines (n=16). Local progression-free survival after radiation therapy alone was assessed using log-rank and Cox proportionate hazard analyses. Intrinsic radiosensitivity was measured as surviving fraction at 2 Gy (SF2) using clonogenic assays. Results: Of the 202 tumors, 107 (53.0%) were positive for HPV16, 29 (14.4%) for HPV18, 9 (4.5%) for HPV45, 23 (11.4%) for other HPV genotypes, and 22 (10.9%) were negative; 11 (5.5%) contained multiple genotypes, and 1 tumor was HPV X (0.5%). In 148 patients with outcome data, those with HPVα9-positive tumors had better local progression-free survival compared with α7 patients in univariate (P

AB - Purpose: To investigate the relationship between human papillomavirus (HPV) genotype and outcome after radiation therapy and intrinsic radiosensitivity. Methods and Materials: HPV genotyping was performed on cervix biopsies by polymerase chain reaction using SPF-10 broad-spectrum primers, followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse hybridization line probe assay (LiPA25) (version 1) (n=202). PapilloCheck and quantitative reverse transcription-polymerase chain reaction were used to genotype cervix cancer cell lines (n=16). Local progression-free survival after radiation therapy alone was assessed using log-rank and Cox proportionate hazard analyses. Intrinsic radiosensitivity was measured as surviving fraction at 2 Gy (SF2) using clonogenic assays. Results: Of the 202 tumors, 107 (53.0%) were positive for HPV16, 29 (14.4%) for HPV18, 9 (4.5%) for HPV45, 23 (11.4%) for other HPV genotypes, and 22 (10.9%) were negative; 11 (5.5%) contained multiple genotypes, and 1 tumor was HPV X (0.5%). In 148 patients with outcome data, those with HPVα9-positive tumors had better local progression-free survival compared with α7 patients in univariate (P

U2 - 10.1016/j.ijrobp.2012.11.030

DO - 10.1016/j.ijrobp.2012.11.030

M3 - Article

C2 - 23332225

VL - 85

SP - e223-e229

JO - International Journal of Radiation: Oncology - Biology - Physics

JF - International Journal of Radiation: Oncology - Biology - Physics

SN - 0360-3016

IS - 5

ER -