Polymorphisms in the PTPN22 region are associated with psoriasis of early onsetCitation formats

  • External authors:
  • R. Ll Smith
  • X. Ke
  • M. Allen
  • D. Strachan
  • W. McArdle
  • M. P. Gittins
  • J. N W N Barker

Standard

Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. / Smith, R. Ll; Warren, Richard; Eyre, S.; Ke, X.; Young, H. S.; Allen, M.; Strachan, D.; McArdle, W.; Gittins, M. P.; Barker, J. N W N; Griffiths, C. E M; Worthington, J.

In: British Journal of Dermatology, Vol. 158, No. 5, 05.2008, p. 962-968.

Research output: Contribution to journalArticlepeer-review

Harvard

Smith, RL, Warren, R, Eyre, S, Ke, X, Young, HS, Allen, M, Strachan, D, McArdle, W, Gittins, MP, Barker, JNWN, Griffiths, CEM & Worthington, J 2008, 'Polymorphisms in the PTPN22 region are associated with psoriasis of early onset', British Journal of Dermatology, vol. 158, no. 5, pp. 962-968. https://doi.org/10.1111/j.1365-2133.2008.08482.x

APA

Smith, R. L., Warren, R., Eyre, S., Ke, X., Young, H. S., Allen, M., Strachan, D., McArdle, W., Gittins, M. P., Barker, J. N. W. N., Griffiths, C. E. M., & Worthington, J. (2008). Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. British Journal of Dermatology, 158(5), 962-968. https://doi.org/10.1111/j.1365-2133.2008.08482.x

Vancouver

Author

Smith, R. Ll ; Warren, Richard ; Eyre, S. ; Ke, X. ; Young, H. S. ; Allen, M. ; Strachan, D. ; McArdle, W. ; Gittins, M. P. ; Barker, J. N W N ; Griffiths, C. E M ; Worthington, J. / Polymorphisms in the PTPN22 region are associated with psoriasis of early onset. In: British Journal of Dermatology. 2008 ; Vol. 158, No. 5. pp. 962-968.

Bibtex

@article{8a1aff294ab145a6b41280cb175c9d43,
title = "Polymorphisms in the PTPN22 region are associated with psoriasis of early onset",
abstract = "Background: Psoriasis, a chronic inflammatory skin disease, affects approximately 2% of the population worldwide. Although the aetiology of psoriasis is poorly understood, patients with disease of early onset (Type I, age of onset ≤ 40 years) usually have a strong genetic component to the disease. Objectives: The purpose of this study was to investigate the role of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene region in susceptibility to Type I psoriasis. Patients and methods: Thirteen single nucleotide polymorphisms (SNPs) mapping to the PTPN22 region were genotyped in 647 patients with Type I psoriasis and 566 normal controls. Results: The rs2476601 (R620W) SNP, widely associated with other inflammatory autoimmune diseases, showed no evidence of association with susceptibility to Type I psoriasis. Two SNPs (rs1217414 and rs3789604) demonstrated significant association with Type I psoriasis and were subsequently genotyped in a further 253 unrelated patients and 2024 normal controls. rs1217414 and rs3789604 were also significantly associated with Type I psoriasis in the combined datasets (P = 0.003 and P = 0.0002, respectively); furthermore carriage of both risk alleles was also significantly associated (P = 0.002). Conclusions: This study demonstrates evidence of association of two SNPs (rs1217414 and rs3789604) in the PTPN22 region with Type I psoriasis, providing evidence for a role of this gene in Type I psoriasis that is not conferred by the R620W variant previously associated with a number of inflammatory diseases. {\textcopyright} 2008 The Authors.",
keywords = "Genetic association, Linkage disequilibrium, Psoriasis, PTPN22",
author = "Smith, {R. Ll} and Richard Warren and S. Eyre and X. Ke and Young, {H. S.} and M. Allen and D. Strachan and W. McArdle and Gittins, {M. P.} and Barker, {J. N W N} and Griffiths, {C. E M} and J. Worthington",
year = "2008",
month = may,
doi = "10.1111/j.1365-2133.2008.08482.x",
language = "English",
volume = "158",
pages = "962--968",
journal = "British Journal of Dermatology",
issn = "0007-0963",
publisher = "John Wiley & Sons Ltd",
number = "5",

}

RIS

TY - JOUR

T1 - Polymorphisms in the PTPN22 region are associated with psoriasis of early onset

AU - Smith, R. Ll

AU - Warren, Richard

AU - Eyre, S.

AU - Ke, X.

AU - Young, H. S.

AU - Allen, M.

AU - Strachan, D.

AU - McArdle, W.

AU - Gittins, M. P.

AU - Barker, J. N W N

AU - Griffiths, C. E M

AU - Worthington, J.

PY - 2008/5

Y1 - 2008/5

N2 - Background: Psoriasis, a chronic inflammatory skin disease, affects approximately 2% of the population worldwide. Although the aetiology of psoriasis is poorly understood, patients with disease of early onset (Type I, age of onset ≤ 40 years) usually have a strong genetic component to the disease. Objectives: The purpose of this study was to investigate the role of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene region in susceptibility to Type I psoriasis. Patients and methods: Thirteen single nucleotide polymorphisms (SNPs) mapping to the PTPN22 region were genotyped in 647 patients with Type I psoriasis and 566 normal controls. Results: The rs2476601 (R620W) SNP, widely associated with other inflammatory autoimmune diseases, showed no evidence of association with susceptibility to Type I psoriasis. Two SNPs (rs1217414 and rs3789604) demonstrated significant association with Type I psoriasis and were subsequently genotyped in a further 253 unrelated patients and 2024 normal controls. rs1217414 and rs3789604 were also significantly associated with Type I psoriasis in the combined datasets (P = 0.003 and P = 0.0002, respectively); furthermore carriage of both risk alleles was also significantly associated (P = 0.002). Conclusions: This study demonstrates evidence of association of two SNPs (rs1217414 and rs3789604) in the PTPN22 region with Type I psoriasis, providing evidence for a role of this gene in Type I psoriasis that is not conferred by the R620W variant previously associated with a number of inflammatory diseases. © 2008 The Authors.

AB - Background: Psoriasis, a chronic inflammatory skin disease, affects approximately 2% of the population worldwide. Although the aetiology of psoriasis is poorly understood, patients with disease of early onset (Type I, age of onset ≤ 40 years) usually have a strong genetic component to the disease. Objectives: The purpose of this study was to investigate the role of the protein tyrosine phosphatase nonreceptor type 22 (PTPN22) gene region in susceptibility to Type I psoriasis. Patients and methods: Thirteen single nucleotide polymorphisms (SNPs) mapping to the PTPN22 region were genotyped in 647 patients with Type I psoriasis and 566 normal controls. Results: The rs2476601 (R620W) SNP, widely associated with other inflammatory autoimmune diseases, showed no evidence of association with susceptibility to Type I psoriasis. Two SNPs (rs1217414 and rs3789604) demonstrated significant association with Type I psoriasis and were subsequently genotyped in a further 253 unrelated patients and 2024 normal controls. rs1217414 and rs3789604 were also significantly associated with Type I psoriasis in the combined datasets (P = 0.003 and P = 0.0002, respectively); furthermore carriage of both risk alleles was also significantly associated (P = 0.002). Conclusions: This study demonstrates evidence of association of two SNPs (rs1217414 and rs3789604) in the PTPN22 region with Type I psoriasis, providing evidence for a role of this gene in Type I psoriasis that is not conferred by the R620W variant previously associated with a number of inflammatory diseases. © 2008 The Authors.

KW - Genetic association

KW - Linkage disequilibrium

KW - Psoriasis

KW - PTPN22

U2 - 10.1111/j.1365-2133.2008.08482.x

DO - 10.1111/j.1365-2133.2008.08482.x

M3 - Article

C2 - 18341666

VL - 158

SP - 962

EP - 968

JO - British Journal of Dermatology

JF - British Journal of Dermatology

SN - 0007-0963

IS - 5

ER -