Polymorphism in molecular crystals: Stabilization of a metastable form by conformational mimicry

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Abstract

A combined modeling and experimental strategy has been applied to the problem of stabilisation of a metastable conformational polymorph. For the first time additives have been successfully selected which by virtue of their conformation are able to selectively inhibit the appearance of the stable β polymorph of L-glutamic acid and hence stabilize the metastable α structure.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1767-1772
Number of pages5
JournalJournal of the American Chemical Society
Volume119
Issue number7
DOIs
Publication statusPublished - 19 Feb 1997