Placental cell turnover in health and diseaseCitation formats

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Placental cell turnover in health and disease. / Heazell, Alexander; Harris, Lynda; Forbes, Karen; Crocker, Ian.

In: Reviews in Gynaecological and Perinatal Practice, Vol. 6, No. 1-2, 06.2006, p. 80-86.

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Heazell, Alexander ; Harris, Lynda ; Forbes, Karen ; Crocker, Ian. / Placental cell turnover in health and disease. In: Reviews in Gynaecological and Perinatal Practice. 2006 ; Vol. 6, No. 1-2. pp. 80-86.

Bibtex

@article{e0fc535aac0446e6ba68964165d2ce26,
title = "Placental cell turnover in health and disease",
abstract = "Pre-eclampsia (PE) and intra-uterine growth restriction (IUGR) cause significant maternal and perinatal morbidity and mortality. Placental dysfunction is central to the development of both conditions. Although the pathophysiology of these conditions is unknown, there is common placental pathology with an increase in apoptotic cell death seen within the trophoblast. In addition, in pre-eclampsia, apoptotic fragments of syncytiotrophoblast have been detected in the maternal circulation. Both hypoxia and reactive oxygen species have been proposed as potential mediators of the insults to the placenta in pre-eclampsia and IUGR resulting in apoptosis. Cell proliferation and apoptosis are tightly regulated by oncoproteins. The increased apoptosis observed within trophoblast is associated with an alteration in oncoprotein expression within placental tissue. Further investigation of these oncoproteins capable of detecting or responding to cell damage may improve understanding of the pathophysiology of pre-eclampsia and IUGR. {\textcopyright} 2006 Elsevier B.V. All rights reserved.",
keywords = "Apoptosis, IUGR, Oncoproteins, Pre-eclampsia",
author = "Alexander Heazell and Lynda Harris and Karen Forbes and Ian Crocker",
year = "2006",
month = jun
doi = "10.1016/j.rigapp.2005.12.003",
language = "English",
volume = "6",
pages = "80--86",
journal = "Reviews in Gynaecological and Perinatal Practice",
issn = "1871-2320",
publisher = "Elsevier BV",
number = "1-2",

}

RIS

TY - JOUR

T1 - Placental cell turnover in health and disease

AU - Heazell, Alexander

AU - Harris, Lynda

AU - Forbes, Karen

AU - Crocker, Ian

PY - 2006/6

Y1 - 2006/6

N2 - Pre-eclampsia (PE) and intra-uterine growth restriction (IUGR) cause significant maternal and perinatal morbidity and mortality. Placental dysfunction is central to the development of both conditions. Although the pathophysiology of these conditions is unknown, there is common placental pathology with an increase in apoptotic cell death seen within the trophoblast. In addition, in pre-eclampsia, apoptotic fragments of syncytiotrophoblast have been detected in the maternal circulation. Both hypoxia and reactive oxygen species have been proposed as potential mediators of the insults to the placenta in pre-eclampsia and IUGR resulting in apoptosis. Cell proliferation and apoptosis are tightly regulated by oncoproteins. The increased apoptosis observed within trophoblast is associated with an alteration in oncoprotein expression within placental tissue. Further investigation of these oncoproteins capable of detecting or responding to cell damage may improve understanding of the pathophysiology of pre-eclampsia and IUGR. © 2006 Elsevier B.V. All rights reserved.

AB - Pre-eclampsia (PE) and intra-uterine growth restriction (IUGR) cause significant maternal and perinatal morbidity and mortality. Placental dysfunction is central to the development of both conditions. Although the pathophysiology of these conditions is unknown, there is common placental pathology with an increase in apoptotic cell death seen within the trophoblast. In addition, in pre-eclampsia, apoptotic fragments of syncytiotrophoblast have been detected in the maternal circulation. Both hypoxia and reactive oxygen species have been proposed as potential mediators of the insults to the placenta in pre-eclampsia and IUGR resulting in apoptosis. Cell proliferation and apoptosis are tightly regulated by oncoproteins. The increased apoptosis observed within trophoblast is associated with an alteration in oncoprotein expression within placental tissue. Further investigation of these oncoproteins capable of detecting or responding to cell damage may improve understanding of the pathophysiology of pre-eclampsia and IUGR. © 2006 Elsevier B.V. All rights reserved.

KW - Apoptosis

KW - IUGR

KW - Oncoproteins

KW - Pre-eclampsia

U2 - 10.1016/j.rigapp.2005.12.003

DO - 10.1016/j.rigapp.2005.12.003

M3 - Article

VL - 6

SP - 80

EP - 86

JO - Reviews in Gynaecological and Perinatal Practice

JF - Reviews in Gynaecological and Perinatal Practice

SN - 1871-2320

IS - 1-2

ER -