Phosphate enrichment of dialysate for use in standard and extended haemodialysis

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Leonard M Ebah
  • Mehvosh Akhtar
  • Ian Wilde
  • Graeme Hookway
  • Mark Vincent
  • Christopher Reeves
  • John Denton
  • John Woods

Abstract

BACKGROUND/AIMS: Intensive haemodialysis (HD) sometimes causes hypophosphataemia, but phosphate-containing dialysate is not readily available. We examined the effectiveness of extemporaneously producing a phosphate-rich dialysate for use in HD.

METHODS: Incremental volumes of Fleet® were added to acid concentrate and predicted to deliver dialysate phosphate concentrations of 0.19-1.1 mmol/l, following mixture with ultrapure water and base concentrate by the HD machine.

RESULTS: The achieved concentrations were close to predicted values (p = 0.77) and remained stable throughout an 8-hour 'treatment' time (p = 0.99). The dialysate phosphate concentration had a linear relationship with the Fleet® volume added, defined by the regression equation y = 172.79 x - 1.47 (R(2) = 0.99, r = 0.99, p = 0.003). The dialysate pH, calcium, magnesium and bicarbonate concentrations did not change over the study period (p = 0.28-0.99). Microscopic analysis under polarised light showed no evidence of crystal formation.

CONCLUSION: The study validates a simple, reliable and cost-effective protocol for phosphate supplementation in conventional and extended HD.

Bibliographical metadata

Original languageEnglish
Pages (from-to)28-33
Number of pages6
JournalBlood Purification
Volume34
Issue number1
DOIs
Publication statusPublished - 2012