PhenomeScape: a Cytoscape app to identify differentially regulated sub-networks using known disease associations

Research output: Contribution to journalArticle

Abstract

Summary: PhenomeScape is a Cytoscape app which provides easy access to the PhenomeExpress algorithm to interpret gene expression data. PhenomeExpress integrates protein interaction networks with known phenotype to gene associations to find active sub-networks enriched in differentially expressed genes. It also incorporates cross-species phenotypes and associations to include results from animal models of disease. With expression data imported into PhenomeScape, the user can quickly generate and visualise interactive sub-networks. PhenomeScape thus enables researchers to use prior knowledge of a disease to identify differentially regulated sub-networks and to generate an overview of altered biologically processes specific to that disease.

Bibliographical metadata

Original languageEnglish
Pages (from-to)3847-9
JournalBioinformatics (Oxford, England)
Volume32
Issue number24
Early online date24 Aug 2016
DOIs
Publication statusPublished - 15 Dec 2016