Aim: TNF inhibitor (TNFi) drugs are a treatment option for rheumatoid arthritis (RA), but response is not universal. Response is typically measured using the composite 4-component (4C) disease activity score 28 (DAS28) which contains more subjective measures. This study used a validated 2-component (2C) DAS28 score to determine whether SNPs associated with response were replicated in a UK population.
Materials & Methods: A literature review identified TNFi response SNPs. Linear regression was conducted to replicate associations with 4C or 2C-DAS28 response.
Results: 18 independent SNPs were analysed in 1828 patients. One and four associations with 4C and 2C-DAS28 response respectively were identified (P<0.05).
Conclusion: Further genetic associations were replicated using the 2C-DAS28 which may reflect the objective nature of 2C-DAS28.