Pharmaceutical hydrates under ambient conditions from high-pressure seeds: A case study of GABA monohydrate

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Abstract

The monohydrate form of the neurotransmitter γ-amino butyric acid (GABA) has been crystallised in the 0.4-0.8 GPa pressure range, recovered to ambient pressure and then used as a seed. Theoretical calculations indicate that this hydrate is only thermodynamically favoured over the two anhydrous forms at high pressures.

Bibliographical metadata

Original languageEnglish
Pages (from-to)1817-1819
Number of pages3
JournalChemical Communications
Volume50
Issue number15
DOIs
Publication statusPublished - 21 Feb 2014

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