“Perfecting” pure shift HSQC: full homodecoupling for accurate and precise determination of heteronuclear couplings

Research output: Research - peer-reviewArticle

  • External authors:
  • L Kaltschnee
  • A Kolmer
  • I Timari
  • V Schmidts
  • K E Kover
  • C M Thiele


Fully homodecoupled HSQC spectra can be obtained through the use of a new pulse sequence element, "perfectBIRD". By way of illustration, we show that perfectBIRD decoupling allows one-bond residual dipolar couplings (RDCs), which provide important NMR restraints for structure elucidation, to be measured with outstanding precision, even in methylene groups.

Bibliographical metadata

Original languageEnglish
Pages (from-to)15702-15705
Number of pages4
JournalChemical Communications
Issue number99
StatePublished - 16 Oct 2014