Patterns of pain over time among children with Juvenile Idiopathic ArthritisCitation formats

  • External authors:
  • Helen E. Foster
  • Eileen Baildam
  • Alice Chieng
  • Joyce E. Davidson
  • Lucy R. Wedderburn
  • Yiannis Ioannou
  • Flora McErlane
  • Wendy Thomson

Standard

Patterns of pain over time among children with Juvenile Idiopathic Arthritis. / Rashid, Amir; Cordingley, Lis; Carrasco, Roberto; Foster, Helen E.; Baildam, Eileen; Chieng, Alice; Davidson, Joyce E.; Wedderburn, Lucy R.; Yiannis Ioannou; McErlane, Flora; Verstappen, Suzanne; Hyrich, Kimme; Thomson, Wendy.

In: Archives of Disease in Childhood, Vol. 103, No. 5, 05.2018, p. 437-442.

Research output: Contribution to journalArticlepeer-review

Harvard

Rashid, A, Cordingley, L, Carrasco, R, Foster, HE, Baildam, E, Chieng, A, Davidson, JE, Wedderburn, LR, Yiannis Ioannou, McErlane, F, Verstappen, S, Hyrich, K & Thomson, W 2018, 'Patterns of pain over time among children with Juvenile Idiopathic Arthritis', Archives of Disease in Childhood, vol. 103, no. 5, pp. 437-442. https://doi.org/10.1136/archdischild-2017-313337

APA

Rashid, A., Cordingley, L., Carrasco, R., Foster, H. E., Baildam, E., Chieng, A., Davidson, J. E., Wedderburn, L. R., Yiannis Ioannou, McErlane, F., Verstappen, S., Hyrich, K., & Thomson, W. (2018). Patterns of pain over time among children with Juvenile Idiopathic Arthritis. Archives of Disease in Childhood, 103(5), 437-442. https://doi.org/10.1136/archdischild-2017-313337

Vancouver

Author

Rashid, Amir ; Cordingley, Lis ; Carrasco, Roberto ; Foster, Helen E. ; Baildam, Eileen ; Chieng, Alice ; Davidson, Joyce E. ; Wedderburn, Lucy R. ; Yiannis Ioannou ; McErlane, Flora ; Verstappen, Suzanne ; Hyrich, Kimme ; Thomson, Wendy. / Patterns of pain over time among children with Juvenile Idiopathic Arthritis. In: Archives of Disease in Childhood. 2018 ; Vol. 103, No. 5. pp. 437-442.

Bibtex

@article{356852a059644fc4b44468e628133951,
title = "Patterns of pain over time among children with Juvenile Idiopathic Arthritis",
abstract = "ObjectivesPain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease-activity alone cannot explain symptoms of pain in all children, suggesting other factors may be relevant. The objectives of this study were to describe the different patterns of pain experienced over time in children with JIA and to identify predictors of which children are likely to experience on-going pain.MethodsThis study used longitudinal-data from patients (aged 1-16 years) with new-onset JIA. Baseline and up to 5-year follow-up pain data from the Childhood Arthritis Prospective Study (CAPS) were used. A two-step approach was adopted. First, pain trajectories were modelled using a discrete mixture-model. Second, multinomial logistic regression was used to determine the association between variables and trajectories.ResultsData from 851 individuals were included (four years, median follow-up). A three-group trajectory model was identified: consistently-low pain (n=453), improved-pain (n=254) and consistently-high pain (n=144). Children with improved-pain or consistently-high pain differed on average at baseline from consistently-low pain. Older age at onset, poor function/disability and longer disease-duration at baseline were associated with consistently-high pain compared to consistently-low pain. Early increases in pain and poor function/disability were also associated with consistently-high pain compared to consistently-low pain. ConclusionsThis study has identified routinely collected clinical factors, which may indicate those individuals with JIA at risk of poor pain-outcomes earlier in disease. Identifying those at highest risk of poor pain-outcomes at disease onset may enable targeted pain management strategies to be implemented early in disease thus reducing the risk of poor pain-outcomes.Funding: ARUK Grant Reference number 20542",
author = "Amir Rashid and Lis Cordingley and Roberto Carrasco and Foster, {Helen E.} and Eileen Baildam and Alice Chieng and Davidson, {Joyce E.} and Wedderburn, {Lucy R.} and {Yiannis Ioannou} and Flora McErlane and Suzanne Verstappen and Kimme Hyrich and Wendy Thomson",
year = "2018",
month = may,
doi = "10.1136/archdischild-2017-313337",
language = "English",
volume = "103",
pages = "437--442",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ ",
number = "5",

}

RIS

TY - JOUR

T1 - Patterns of pain over time among children with Juvenile Idiopathic Arthritis

AU - Rashid, Amir

AU - Cordingley, Lis

AU - Carrasco, Roberto

AU - Foster, Helen E.

AU - Baildam, Eileen

AU - Chieng, Alice

AU - Davidson, Joyce E.

AU - Wedderburn, Lucy R.

AU - Yiannis Ioannou,

AU - McErlane, Flora

AU - Verstappen, Suzanne

AU - Hyrich, Kimme

AU - Thomson, Wendy

PY - 2018/5

Y1 - 2018/5

N2 - ObjectivesPain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease-activity alone cannot explain symptoms of pain in all children, suggesting other factors may be relevant. The objectives of this study were to describe the different patterns of pain experienced over time in children with JIA and to identify predictors of which children are likely to experience on-going pain.MethodsThis study used longitudinal-data from patients (aged 1-16 years) with new-onset JIA. Baseline and up to 5-year follow-up pain data from the Childhood Arthritis Prospective Study (CAPS) were used. A two-step approach was adopted. First, pain trajectories were modelled using a discrete mixture-model. Second, multinomial logistic regression was used to determine the association between variables and trajectories.ResultsData from 851 individuals were included (four years, median follow-up). A three-group trajectory model was identified: consistently-low pain (n=453), improved-pain (n=254) and consistently-high pain (n=144). Children with improved-pain or consistently-high pain differed on average at baseline from consistently-low pain. Older age at onset, poor function/disability and longer disease-duration at baseline were associated with consistently-high pain compared to consistently-low pain. Early increases in pain and poor function/disability were also associated with consistently-high pain compared to consistently-low pain. ConclusionsThis study has identified routinely collected clinical factors, which may indicate those individuals with JIA at risk of poor pain-outcomes earlier in disease. Identifying those at highest risk of poor pain-outcomes at disease onset may enable targeted pain management strategies to be implemented early in disease thus reducing the risk of poor pain-outcomes.Funding: ARUK Grant Reference number 20542

AB - ObjectivesPain is a very common symptom of juvenile idiopathic arthritis (JIA). Disease-activity alone cannot explain symptoms of pain in all children, suggesting other factors may be relevant. The objectives of this study were to describe the different patterns of pain experienced over time in children with JIA and to identify predictors of which children are likely to experience on-going pain.MethodsThis study used longitudinal-data from patients (aged 1-16 years) with new-onset JIA. Baseline and up to 5-year follow-up pain data from the Childhood Arthritis Prospective Study (CAPS) were used. A two-step approach was adopted. First, pain trajectories were modelled using a discrete mixture-model. Second, multinomial logistic regression was used to determine the association between variables and trajectories.ResultsData from 851 individuals were included (four years, median follow-up). A three-group trajectory model was identified: consistently-low pain (n=453), improved-pain (n=254) and consistently-high pain (n=144). Children with improved-pain or consistently-high pain differed on average at baseline from consistently-low pain. Older age at onset, poor function/disability and longer disease-duration at baseline were associated with consistently-high pain compared to consistently-low pain. Early increases in pain and poor function/disability were also associated with consistently-high pain compared to consistently-low pain. ConclusionsThis study has identified routinely collected clinical factors, which may indicate those individuals with JIA at risk of poor pain-outcomes earlier in disease. Identifying those at highest risk of poor pain-outcomes at disease onset may enable targeted pain management strategies to be implemented early in disease thus reducing the risk of poor pain-outcomes.Funding: ARUK Grant Reference number 20542

U2 - 10.1136/archdischild-2017-313337

DO - 10.1136/archdischild-2017-313337

M3 - Article

VL - 103

SP - 437

EP - 442

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - 5

ER -