P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair lossCitation formats
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P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. / Brosh, Ran; Sarig, Rachel; Natan, Elad Bar; Molchadsky, Alina; Madar, Shalom; Bornstein, Chamutal; Buganim, Yosef; Shapira, Tirosh; Goldfinger, Naomi; Paus, Ralf; Rotter, Varda.
In: FEBS Letters, Vol. 584, No. 11, 06.2010, p. 2473-2477.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss
AU - Brosh, Ran
AU - Sarig, Rachel
AU - Natan, Elad Bar
AU - Molchadsky, Alina
AU - Madar, Shalom
AU - Bornstein, Chamutal
AU - Buganim, Yosef
AU - Shapira, Tirosh
AU - Goldfinger, Naomi
AU - Paus, Ralf
AU - Rotter, Varda
PY - 2010/6
Y1 - 2010/6
N2 - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.
AB - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.
KW - Alopecia
KW - Chemotherapy-induced alopecia
KW - Cyclophosphamide
KW - Knockout
KW - XEDAR
U2 - 10.1016/j.febslet.2010.04.058
DO - 10.1016/j.febslet.2010.04.058
M3 - Article
C2 - 20434500
VL - 584
SP - 2473
EP - 2477
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 11
ER -