P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair lossCitation formats

  • External authors:
  • Ran Brosh
  • Rachel Sarig
  • Elad Bar Natan
  • Alina Molchadsky
  • Shalom Madar
  • Chamutal Bornstein
  • Yosef Buganim
  • Tirosh Shapira
  • Naomi Goldfinger
  • Varda Rotter

Standard

P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. / Brosh, Ran; Sarig, Rachel; Natan, Elad Bar; Molchadsky, Alina; Madar, Shalom; Bornstein, Chamutal; Buganim, Yosef; Shapira, Tirosh; Goldfinger, Naomi; Paus, Ralf; Rotter, Varda.

In: FEBS Letters, Vol. 584, No. 11, 06.2010, p. 2473-2477.

Research output: Contribution to journalArticle

Harvard

Brosh, R, Sarig, R, Natan, EB, Molchadsky, A, Madar, S, Bornstein, C, Buganim, Y, Shapira, T, Goldfinger, N, Paus, R & Rotter, V 2010, 'P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss', FEBS Letters, vol. 584, no. 11, pp. 2473-2477. https://doi.org/10.1016/j.febslet.2010.04.058

APA

Brosh, R., Sarig, R., Natan, E. B., Molchadsky, A., Madar, S., Bornstein, C., ... Rotter, V. (2010). P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. FEBS Letters, 584(11), 2473-2477. https://doi.org/10.1016/j.febslet.2010.04.058

Vancouver

Brosh R, Sarig R, Natan EB, Molchadsky A, Madar S, Bornstein C et al. P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. FEBS Letters. 2010 Jun;584(11):2473-2477. https://doi.org/10.1016/j.febslet.2010.04.058

Author

Brosh, Ran ; Sarig, Rachel ; Natan, Elad Bar ; Molchadsky, Alina ; Madar, Shalom ; Bornstein, Chamutal ; Buganim, Yosef ; Shapira, Tirosh ; Goldfinger, Naomi ; Paus, Ralf ; Rotter, Varda. / P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss. In: FEBS Letters. 2010 ; Vol. 584, No. 11. pp. 2473-2477.

Bibtex

@article{46bbe642b5c84e16bfdb225852849a96,
title = "P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss",
abstract = "The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. {\circledC} 2010 Federation of European Biochemical Societies.",
keywords = "Alopecia, Chemotherapy-induced alopecia, Cyclophosphamide, Knockout, XEDAR",
author = "Ran Brosh and Rachel Sarig and Natan, {Elad Bar} and Alina Molchadsky and Shalom Madar and Chamutal Bornstein and Yosef Buganim and Tirosh Shapira and Naomi Goldfinger and Ralf Paus and Varda Rotter",
year = "2010",
month = "6",
doi = "10.1016/j.febslet.2010.04.058",
language = "English",
volume = "584",
pages = "2473--2477",
journal = "FEBS Lett",
issn = "0014-5793",
publisher = "Elsevier BV",
number = "11",

}

RIS

TY - JOUR

T1 - P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

AU - Brosh, Ran

AU - Sarig, Rachel

AU - Natan, Elad Bar

AU - Molchadsky, Alina

AU - Madar, Shalom

AU - Bornstein, Chamutal

AU - Buganim, Yosef

AU - Shapira, Tirosh

AU - Goldfinger, Naomi

AU - Paus, Ralf

AU - Rotter, Varda

PY - 2010/6

Y1 - 2010/6

N2 - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.

AB - The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.

KW - Alopecia

KW - Chemotherapy-induced alopecia

KW - Cyclophosphamide

KW - Knockout

KW - XEDAR

U2 - 10.1016/j.febslet.2010.04.058

DO - 10.1016/j.febslet.2010.04.058

M3 - Article

VL - 584

SP - 2473

EP - 2477

JO - FEBS Lett

JF - FEBS Lett

SN - 0014-5793

IS - 11

ER -