P53-dependent transcriptional regulation of EDA2R and its involvement in chemotherapy-induced hair loss

Research output: Contribution to journalArticle

  • External authors:
  • Ran Brosh
  • Rachel Sarig
  • Elad Bar Natan
  • Alina Molchadsky
  • Shalom Madar
  • Chamutal Bornstein
  • Yosef Buganim
  • Tirosh Shapira
  • Naomi Goldfinger
  • Varda Rotter

Abstract

The p53 tumor suppressor coordinates a multitude of cellular and organismal processes and exerts its activities mainly by activation of gene transcription. Here we describe the transcriptional activation of ectodysplasin A2 receptor (EDA2R) by p53 in a variety of cell types and tissues. We demonstrate that treatment of cancer cells with the ligand EDA-A2, known to specifically activate EDA2R, results in p53-dependent cell death. Moreover, we show that EDA2R is transactivated by p53 during chemotherapy-induced hair-loss, although its presence is not necessary for this process. These data shed new light on the role of EDA2R in exerting p53 function. © 2010 Federation of European Biochemical Societies.

Bibliographical metadata

Original languageEnglish
Pages (from-to)2473-2477
Number of pages4
JournalFEBS Letters
Volume584
Issue number11
DOIs
Publication statusPublished - Jun 2010