Osteopontin as a new player in mast cell biologyCitation formats

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Osteopontin as a new player in mast cell biology. / Bulfone-Paus, Silvia; Paus, Ralf.

In: European journal of immunology, Vol. 38, No. 2, 02.2008, p. 338-341.

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Bulfone-Paus, Silvia ; Paus, Ralf. / Osteopontin as a new player in mast cell biology. In: European journal of immunology. 2008 ; Vol. 38, No. 2. pp. 338-341.

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@article{9d573b5b2d874d60af5845291984bc03,
title = "Osteopontin as a new player in mast cell biology",
abstract = "The secreted glycoprotein osteopontin (OPN) sets into motion an astounding variety of activities that range from bone remodeling via immunomodulation to the inhibition of apoptosis. In the current issue of the.European Journal of Immunology, OPN now also enters mast cell biology and the regulation of IgE-dependent immune responses since it is reported that connective tissue-type mast cells from fetal murine skin constitutively secrete biologically active OPN. Moreover, it is shown that, in vitro, OPN augments IgE-mediated mast cell degranulation and migration via ligand binding to cognate OPN receptors on the mast cell surface (CD44, αv integrin) and that the magnitude of an IgE-mediated passive cutaneous anaphylaxis reaction is augmented by OPN in vivo. Here, we discuss why this newly discovered property of OPN fits well into the emerging concept that OPN may serve as a multi-purpose environmental damage-response protein. {\circledC} 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",
keywords = "Allergy, Cytokines, IgE, Mast cells",
author = "Silvia Bulfone-Paus and Ralf Paus",
year = "2008",
month = "2",
doi = "10.1002/eji.200738131",
language = "English",
volume = "38",
pages = "338--341",
journal = "European journal of immunology",
issn = "1521-4141",
publisher = "John Wiley & Sons Ltd",
number = "2",

}

RIS

TY - JOUR

T1 - Osteopontin as a new player in mast cell biology

AU - Bulfone-Paus, Silvia

AU - Paus, Ralf

PY - 2008/2

Y1 - 2008/2

N2 - The secreted glycoprotein osteopontin (OPN) sets into motion an astounding variety of activities that range from bone remodeling via immunomodulation to the inhibition of apoptosis. In the current issue of the.European Journal of Immunology, OPN now also enters mast cell biology and the regulation of IgE-dependent immune responses since it is reported that connective tissue-type mast cells from fetal murine skin constitutively secrete biologically active OPN. Moreover, it is shown that, in vitro, OPN augments IgE-mediated mast cell degranulation and migration via ligand binding to cognate OPN receptors on the mast cell surface (CD44, αv integrin) and that the magnitude of an IgE-mediated passive cutaneous anaphylaxis reaction is augmented by OPN in vivo. Here, we discuss why this newly discovered property of OPN fits well into the emerging concept that OPN may serve as a multi-purpose environmental damage-response protein. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - The secreted glycoprotein osteopontin (OPN) sets into motion an astounding variety of activities that range from bone remodeling via immunomodulation to the inhibition of apoptosis. In the current issue of the.European Journal of Immunology, OPN now also enters mast cell biology and the regulation of IgE-dependent immune responses since it is reported that connective tissue-type mast cells from fetal murine skin constitutively secrete biologically active OPN. Moreover, it is shown that, in vitro, OPN augments IgE-mediated mast cell degranulation and migration via ligand binding to cognate OPN receptors on the mast cell surface (CD44, αv integrin) and that the magnitude of an IgE-mediated passive cutaneous anaphylaxis reaction is augmented by OPN in vivo. Here, we discuss why this newly discovered property of OPN fits well into the emerging concept that OPN may serve as a multi-purpose environmental damage-response protein. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - Allergy

KW - Cytokines

KW - IgE

KW - Mast cells

U2 - 10.1002/eji.200738131

DO - 10.1002/eji.200738131

M3 - Article

VL - 38

SP - 338

EP - 341

JO - European journal of immunology

JF - European journal of immunology

SN - 1521-4141

IS - 2

ER -