On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrierCitation formats

  • External authors:
  • Nicolas Dutzan
  • Loreto Abusleme
  • Hayley Bridgeman
  • Teresa Greenwell-Wild
  • Tamsin Zangerle Murray
  • Mark Fife
  • Nicolas Bouladoux
  • Holly Linley
  • Laurie Brenchley
  • Kelly Wemyss
  • Gloria Calderon
  • Bo-Young Hong
  • Timothy. J Break
  • Dawn. M. E Bowdish
  • Michail. S Lionakis
  • Simon A Jones
  • Giorgio Trinchieri
  • Patricia.I. Diaz
  • Yasmine Belkaid
  • Niki M Moutsopoulos

Standard

On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier. / Dutzan, Nicolas; Abusleme, Loreto; Bridgeman, Hayley; Greenwell-Wild, Teresa; Zangerle Murray, Tamsin; Fife, Mark; Bouladoux, Nicolas; Linley, Holly; Brenchley, Laurie; Wemyss, Kelly; Calderon, Gloria; Hong, Bo-Young; Break, Timothy. J; Bowdish, Dawn. M. E; Lionakis, Michail. S; Jones, Simon A; Trinchieri, Giorgio; Diaz, Patricia.I.; Belkaid, Yasmine; Konkel, Joanne; Moutsopoulos, Niki M.

In: Immunity, 17.01.2017.

Research output: Contribution to journalArticle

Harvard

Dutzan, N, Abusleme, L, Bridgeman, H, Greenwell-Wild, T, Zangerle Murray, T, Fife, M, Bouladoux, N, Linley, H, Brenchley, L, Wemyss, K, Calderon, G, Hong, B-Y, Break, TJ, Bowdish, DME, Lionakis, MS, Jones, SA, Trinchieri, G, Diaz, PI, Belkaid, Y, Konkel, J & Moutsopoulos, NM 2017, 'On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier' Immunity. https://doi.org/10.1016/j.immuni.2016.12.010

APA

Dutzan, N., Abusleme, L., Bridgeman, H., Greenwell-Wild, T., Zangerle Murray, T., Fife, M., ... Moutsopoulos, N. M. (2017). On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier. Immunity. https://doi.org/10.1016/j.immuni.2016.12.010

Vancouver

Dutzan N, Abusleme L, Bridgeman H, Greenwell-Wild T, Zangerle Murray T, Fife M et al. On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier. Immunity. 2017 Jan 17. https://doi.org/10.1016/j.immuni.2016.12.010

Author

Dutzan, Nicolas ; Abusleme, Loreto ; Bridgeman, Hayley ; Greenwell-Wild, Teresa ; Zangerle Murray, Tamsin ; Fife, Mark ; Bouladoux, Nicolas ; Linley, Holly ; Brenchley, Laurie ; Wemyss, Kelly ; Calderon, Gloria ; Hong, Bo-Young ; Break, Timothy. J ; Bowdish, Dawn. M. E ; Lionakis, Michail. S ; Jones, Simon A ; Trinchieri, Giorgio ; Diaz, Patricia.I. ; Belkaid, Yasmine ; Konkel, Joanne ; Moutsopoulos, Niki M. / On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier. In: Immunity. 2017.

Bibtex

@article{9de7c85b0a92497f96b3fc0e9574e50c,
title = "On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier",
abstract = "Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization-independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier.",
author = "Nicolas Dutzan and Loreto Abusleme and Hayley Bridgeman and Teresa Greenwell-Wild and {Zangerle Murray}, Tamsin and Mark Fife and Nicolas Bouladoux and Holly Linley and Laurie Brenchley and Kelly Wemyss and Gloria Calderon and Bo-Young Hong and Break, {Timothy. J} and Bowdish, {Dawn. M. E} and Lionakis, {Michail. S} and Jones, {Simon A} and Giorgio Trinchieri and Patricia.I. Diaz and Yasmine Belkaid and Joanne Konkel and Moutsopoulos, {Niki M}",
year = "2017",
month = "1",
day = "17",
doi = "10.1016/j.immuni.2016.12.010",
language = "English",
journal = "Immunity",
issn = "1074-7613",
publisher = "Cell Press",

}

RIS

TY - JOUR

T1 - On-going mechanical damage from mastication drives homeostatic Th17 responses at the oral barrier

AU - Dutzan, Nicolas

AU - Abusleme, Loreto

AU - Bridgeman, Hayley

AU - Greenwell-Wild, Teresa

AU - Zangerle Murray, Tamsin

AU - Fife, Mark

AU - Bouladoux, Nicolas

AU - Linley, Holly

AU - Brenchley, Laurie

AU - Wemyss, Kelly

AU - Calderon, Gloria

AU - Hong, Bo-Young

AU - Break, Timothy. J

AU - Bowdish, Dawn. M. E

AU - Lionakis, Michail. S

AU - Jones, Simon A

AU - Trinchieri, Giorgio

AU - Diaz, Patricia.I.

AU - Belkaid, Yasmine

AU - Konkel, Joanne

AU - Moutsopoulos, Niki M

PY - 2017/1/17

Y1 - 2017/1/17

N2 - Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization-independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier.

AB - Immuno-surveillance networks operating at barrier sites are tuned by local tissue cues to ensure effective immunity. Site-specific commensal bacteria provide key signals ensuring host defense in the skin and gut. However, how the oral microbiome and tissue-specific signals balance immunity and regulation at the gingiva, a key oral barrier, remains minimally explored. In contrast to the skin and gut, we demonstrate that gingiva-resident T helper 17 (Th17) cells developed via a commensal colonization-independent mechanism. Accumulation of Th17 cells at the gingiva was driven in response to the physiological barrier damage that occurs during mastication. Physiological mechanical damage, via induction of interleukin 6 (IL-6) from epithelial cells, tailored effector T cell function, promoting increases in gingival Th17 cell numbers. These data highlight that diverse tissue-specific mechanisms govern education of Th17 cell responses and demonstrate that mechanical damage helps define the immune tone of this important oral barrier.

U2 - 10.1016/j.immuni.2016.12.010

DO - 10.1016/j.immuni.2016.12.010

M3 - Article

JO - Immunity

JF - Immunity

SN - 1074-7613

ER -