Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic ChannelCitation formats

Standard

Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel. / Shahbazi, Fatemeh; Jabbari, Masoud; Esfahani, Mohammad Nasr; Keshmiri, Amir.

8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. ed. / Tomaz Jarm; Aleksandra Cvetkoska; Samo Mahnič-Kalamiza; Damijan Miklavcic. Springer Nature, 2021. p. 905-914 (IFMBE Proceedings; Vol. 80).

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Harvard

Shahbazi, F, Jabbari, M, Esfahani, MN & Keshmiri, A 2021, Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel. in T Jarm, A Cvetkoska, S Mahnič-Kalamiza & D Miklavcic (eds), 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. IFMBE Proceedings, vol. 80, Springer Nature, pp. 905-914, 8th European Medical and Biological Engineering Conference, EMBEC 2020, Portorož, Slovenia, 29/11/20. https://doi.org/10.1007/978-3-030-64610-3_101

APA

Shahbazi, F., Jabbari, M., Esfahani, M. N., & Keshmiri, A. (2021). Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel. In T. Jarm, A. Cvetkoska, S. Mahnič-Kalamiza, & D. Miklavcic (Eds.), 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020 (pp. 905-914). (IFMBE Proceedings; Vol. 80). Springer Nature. https://doi.org/10.1007/978-3-030-64610-3_101

Vancouver

Shahbazi F, Jabbari M, Esfahani MN, Keshmiri A. Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel. In Jarm T, Cvetkoska A, Mahnič-Kalamiza S, Miklavcic D, editors, 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. Springer Nature. 2021. p. 905-914. (IFMBE Proceedings). https://doi.org/10.1007/978-3-030-64610-3_101

Author

Shahbazi, Fatemeh ; Jabbari, Masoud ; Esfahani, Mohammad Nasr ; Keshmiri, Amir. / Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel. 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020. editor / Tomaz Jarm ; Aleksandra Cvetkoska ; Samo Mahnič-Kalamiza ; Damijan Miklavcic. Springer Nature, 2021. pp. 905-914 (IFMBE Proceedings).

Bibtex

@inproceedings{9a1e7a35d0b247188f6c0ea9f211d355,
title = "Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel",
abstract = "Use of heterogeneous biosensors in microfluidic channels for diagnostic and detection of diseases in early stages is a novel, relatively cheap and applicable solution for saving lives and health purposes. It has attracted great interest in experimental field and a lot of works are being done in order to reach better biosensors with reliable results and fast detection. A comprehensive numerical model of Langmuir-Hinshelwood mechanism would help speeding up the process of design and analysis of biosensors. For this means we have developed a code in Fortran to simulate flow inside a microfluidic channel combined with Langmuir-Hinshelwood reactions on the surface of the biosensor. Control-volume based finite-element method (CVFEM) with high order discretisation has been used to solve full Navier-Stokes equations with chemical reactions on the biosensor. Results has been validated with existing experimental data from literature. The influence of target concentration as well as the inlet velocity (flow rate replica) on the biosensor saturation time, moreover, investigated in this study. The results show that as the inlet velocity and concentration increases the time that concentration on the surface of biosensor reaches its asymptotic value decreases, although increase in inlet velocity does not have any effect on dissociation stage of binding cycle.",
keywords = "Biosensors, CFD, CVFEM, Microfluidics",
author = "Fatemeh Shahbazi and Masoud Jabbari and Esfahani, {Mohammad Nasr} and Amir Keshmiri",
note = "Funding Information: The first author would like to thank the Department of MACE at the University of Manchester for providing PhD funding under the ?Exceptional Women in Engineering? scheme. Publisher Copyright: {\textcopyright} 2021, Springer Nature Switzerland AG. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.; 8th European Medical and Biological Engineering Conference, EMBEC 2020 ; Conference date: 29-11-2020 Through 03-12-2020",
year = "2021",
doi = "10.1007/978-3-030-64610-3_101",
language = "English",
isbn = "9783030646097",
series = "IFMBE Proceedings",
publisher = "Springer Nature",
pages = "905--914",
editor = "Tomaz Jarm and Aleksandra Cvetkoska and Samo Mahni{\v c}-Kalamiza and Damijan Miklavcic",
booktitle = "8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020",
address = "United States",

}

RIS

TY - GEN

T1 - Numerical Simulation of Langmuir-Hinshelwood Mechanism for Heterogeneous Biosensors in Microfluidic Channel

AU - Shahbazi, Fatemeh

AU - Jabbari, Masoud

AU - Esfahani, Mohammad Nasr

AU - Keshmiri, Amir

N1 - Funding Information: The first author would like to thank the Department of MACE at the University of Manchester for providing PhD funding under the ?Exceptional Women in Engineering? scheme. Publisher Copyright: © 2021, Springer Nature Switzerland AG. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Use of heterogeneous biosensors in microfluidic channels for diagnostic and detection of diseases in early stages is a novel, relatively cheap and applicable solution for saving lives and health purposes. It has attracted great interest in experimental field and a lot of works are being done in order to reach better biosensors with reliable results and fast detection. A comprehensive numerical model of Langmuir-Hinshelwood mechanism would help speeding up the process of design and analysis of biosensors. For this means we have developed a code in Fortran to simulate flow inside a microfluidic channel combined with Langmuir-Hinshelwood reactions on the surface of the biosensor. Control-volume based finite-element method (CVFEM) with high order discretisation has been used to solve full Navier-Stokes equations with chemical reactions on the biosensor. Results has been validated with existing experimental data from literature. The influence of target concentration as well as the inlet velocity (flow rate replica) on the biosensor saturation time, moreover, investigated in this study. The results show that as the inlet velocity and concentration increases the time that concentration on the surface of biosensor reaches its asymptotic value decreases, although increase in inlet velocity does not have any effect on dissociation stage of binding cycle.

AB - Use of heterogeneous biosensors in microfluidic channels for diagnostic and detection of diseases in early stages is a novel, relatively cheap and applicable solution for saving lives and health purposes. It has attracted great interest in experimental field and a lot of works are being done in order to reach better biosensors with reliable results and fast detection. A comprehensive numerical model of Langmuir-Hinshelwood mechanism would help speeding up the process of design and analysis of biosensors. For this means we have developed a code in Fortran to simulate flow inside a microfluidic channel combined with Langmuir-Hinshelwood reactions on the surface of the biosensor. Control-volume based finite-element method (CVFEM) with high order discretisation has been used to solve full Navier-Stokes equations with chemical reactions on the biosensor. Results has been validated with existing experimental data from literature. The influence of target concentration as well as the inlet velocity (flow rate replica) on the biosensor saturation time, moreover, investigated in this study. The results show that as the inlet velocity and concentration increases the time that concentration on the surface of biosensor reaches its asymptotic value decreases, although increase in inlet velocity does not have any effect on dissociation stage of binding cycle.

KW - Biosensors

KW - CFD

KW - CVFEM

KW - Microfluidics

UR - http://www.scopus.com/inward/record.url?scp=85097598659&partnerID=8YFLogxK

U2 - 10.1007/978-3-030-64610-3_101

DO - 10.1007/978-3-030-64610-3_101

M3 - Conference contribution

AN - SCOPUS:85097598659

SN - 9783030646097

T3 - IFMBE Proceedings

SP - 905

EP - 914

BT - 8th European Medical and Biological Engineering Conference - Proceedings of the EMBEC 2020

A2 - Jarm, Tomaz

A2 - Cvetkoska, Aleksandra

A2 - Mahnič-Kalamiza, Samo

A2 - Miklavcic, Damijan

PB - Springer Nature

T2 - 8th European Medical and Biological Engineering Conference, EMBEC 2020

Y2 - 29 November 2020 through 3 December 2020

ER -