Nuclear quantum tunnelling in enzymatic reactions - an enzymologist's perspective.

Research output: Research - peer-reviewArticle


Enzyme-catalysed H-transfer reactions are ubiquitous, yet fundamental details of these reactions remain unresolved. In this perspective, we discuss the roles of nuclear quantum tunnelling and (compressive) dynamics during these reactions. Evidence for the coupling of specific substrate and/or protein vibrations to the chemical coordinate is considered and a case is made for the combination of multiple experimental and computational/theoretical approaches when studying these reactions.

Bibliographical metadata

Original languageEnglish
Pages (from-to)30775-30782
Number of pages8
JournalPhysical Chemistry Chemical Physics
Issue number46
StatePublished - 18 Nov 2015

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