Normal tissue reactions to radiotherapy: Towards tailoring treatment dose by genotype

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Gillian C. Barnett
  • Alison M. Dunning
  • Rebecca M. Elliott
  • Charlotte E. Coles
  • Paul D P Pharoah
  • Neil G. Burnet


A key challenge in radiotherapy is to maximize radiation doses to cancer cells while minimizing damage to surrounding healthy tissue. As severe toxicity in a minority of patients limits the doses that can be safely given to the majority, there is interest in developing a test to measure an individual's radiosensitivity before treatment. Variation in sensitivity to radiation is an inherited genetic trait and recent progress in genotyping raises the possibility of genome-wide studies to characterize genetic profiles that predict patient response to radiotherapy. © 2009 Macmillan Publishers Limited. All rights reserved.

Bibliographical metadata

Original languageEnglish
Pages (from-to)134-142
Number of pages8
JournalNature Reviews Cancer
Issue number2
Publication statusPublished - Feb 2009