Neither proteinuria nor albuminuria is associated with endothelial dysfunction in HIV-infected patients without diabetes or hypertension

Research output: Chapter in Book/Report/Conference proceedingChapter

  • Authors:
  • Reza Aghamohammadzadeh
  • Samir K. Gupta
  • Changyu Shen
  • Kieren J. Mather
  • Rajiv Agarwal
  • And 1 others
  • External authors:
  • Michael P. Dubé

Abstract

It is unknown whether systemic endothelial dysfunction underlies the association between nephropathy and cardiovascular disease (CVD) in persons infected with human immunodeficiency virus (HIV). Spot urine protein to creatinine ratio, spot urine albumin to creatinine ratio, creatinine clearance, estimated glomerular filtration rate, and flow-mediated dilation (FMD) of the brachial artery were evaluated in 123 study participants infected with HIV (58 receiving antiretroviral therapy [ART] and 65 not receiving ART) with no history of diabetes or hypertension. None of the renal markers, modeled as either continuous or categorical variables, correlated with FMD. Contrary to expectations, endothelial dysfunction may not be the link between nephropathy and CVD in HIV. © 2011 The Author.

Bibliographical metadata

Original languageEnglish
Title of host publicationJournal of Infectious Diseases|J. Infect. Dis.
Place of PublicationOnline
PublisherINTECH
Pages1946-1950
Number of pages4
Volume204
Edition1
DOIs
Publication statusPublished - 15 Dec 2011