Needles from haystacks: single‐scan selective excitation of individual NMR signals in overlapping multiplets

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Peter Kiraly
  • Nicolas Kern
  • Mateusz P. Plesniak

Abstract

2D NMR is an immensely powerful structural tool, but time‐consuming. Targeting individual chemical groups by selective excitation in a 1D experiment can give the information required far more quickly. A major problem, however, is that proton NMR spectra are often extensively overlapped, so that in practice only a minority of sites can be selectively excited. Here we overcome that problem using a fast, single‐scan method that allows selective excitation of the signals of a single proton multiplet even where it is severely overlapped by other multiplets. The advantages of the method are illustrated in a selective 1D NOESY experiment, the most efficient way to determine relative configuration unambiguously by NMR. The new approach presented here has the potential to broaden significantly the applicability of selective excitation, and unlock its real potential for many other experiments.

Bibliographical metadata

Original languageEnglish
JournalAngewandte Chemie International Edition
Early online date23 Sep 2020
DOIs
Publication statusPublished - 23 Sep 2020

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