Necrotic, ulcerative bronchitis, the presenting feature of lymphoproliferative disease following heart-lung transplantation

Research output: Contribution to journalArticle

  • Authors:
  • J. J. Egan
  • P. S. Hasleton
  • N. Yonan
  • A. N. Rahman
  • A. K. Deiraniya
  • And 1 others
  • External authors:
  • K. B A A Carroll Woodcock

Abstract

Following heart-lung transplantation two of 21 patients who survived more than 100 days developed post-transplant lymphoproliferative disease. Both presented with localised ulcerative bronchitis documented at flexible bronchoscopy four months after transplantation. Histological examination showed necrosis with acute inflammation and ulceration. Case 2 demonstrated lymphoproliferative disease from biopsies subsequently taken at rigid bronchoscopy. Case 1 later developed lung nodules and a monoclonal high grade B cell non-Hodgkin's lymphoma was confirmed by an open lung biopsy. The bronchoscopic features described should alert clinicians to post-transplant lymphoproliferative disease as an underlying diagnosis and suggest that bronchus associated lymphoid tissue is the initial site for clonal proliferation in the disease.

Bibliographical metadata

Original languageEnglish
Pages (from-to)205-207
Number of pages2
JournalThorax
Volume50
Issue number2
Publication statusPublished - 1995