Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Neazar E Baghdadi
  • Benjamin P Burke
  • Tahani Alresheedi
  • Shubhanchi Nigam
  • Abdu Saeed
  • Farooq Almutairi
  • Juozas Domarkas
  • Stephen J Archibald

Abstract

The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.

Bibliographical metadata

Original languageEnglish
JournalDalton Transactions
DOIs
Publication statusPublished - 27 Jan 2021