Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Research output: Contribution to journalArticlepeer-review

  • External authors:
  • Wasco Wruck
  • Karl Kashofer
  • Andriani Daskalaki
  • Daniela Berg
  • Ewa Gralka
  • Justyna Jozefczuk
  • Katharina Drews
  • Vikash Pandey
  • Christian Regenbrecht
  • Christoph Wierling
  • Paola Turano
  • Ulrike Korf
  • Kurt Zatloukal
  • Hans Lehrach
  • Hans V Westerhoff
  • James Adjaye

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxicity. Additionally, polymorphisms within, e.g., APOC3, PNPLA3, NCAN, TM6SF2 and PPP1R3B, correlate with NAFLD. Several studies have already investigated later stages of the disease. This study explores the early steatosis stage of NAFLD with the aim of identifying molecular mechanisms underlying the etiology of NAFLD. We analyzed liver biopsies and serum samples from patients with high- and low-grade steatosis (also pre-disease states) employing transcriptomics, ELISA-based serum protein analyses and metabolomics. Here, we provide a detailed description of the various related datasets produced in the course of this study. These datasets may help other researchers find new clues for the etiology of NAFLD and the mechanisms underlying its progression to more severe disease states.

Bibliographical metadata

Original languageEnglish
Pages (from-to)150068
JournalScientific Data
Volume2
DOIs
Publication statusPublished - 8 Dec 2015