Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.Citation formats
Standard
Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. / Neafsey, Daniel E; Waterhouse, Robert M; Abai, Mohammad R; Aganezov, Sergey S; Alekseyev, Max A; Allen, James E; Amon, James; Arcà, Bruno; Arensburger, Peter; Artemov, Gleb; Assour, Lauren A; Basseri, Hamidreza; Berlin, Aaron; Birren, Bruce W; Blandin, Stephanie A; Brockman, Andrew I; Burkot, Thomas R; Burt, Austin; Chan, Clara S; Chauve, Cedric; Chiu, Joanna C; Christensen, Mikkel; Costantini, Carlo; Davidson, Victoria L M; Deligianni, Elena; Dottorini, Tania; Dritsou, Vicky; Gabriel, Stacey B; Guelbeogo, Wamdaogo M; Hall, Andrew B; Han, Mira V; Hlaing, Thaung; Hughes, Daniel S T; Jenkins, Adam M; Jiang, Xiaofang; Jungreis, Irwin; Kakani, Evdoxia G; Kamali, Maryam; Kemppainen, Petri; Kennedy, Ryan C; Kirmitzoglou, Ioannis K; Koekemoer, Lizette L; Laban, Njoroge; Langridge, Nicholas; Lawniczak, Mara K N; Lirakis, Manolis; Lobo, Neil F; Lowy, Ernesto; MacCallum, Robert M; Mao, Chunhong; Maslen, Gareth; Mbogo, Charles; McCarthy, Jenny; Michel, Kristin; Mitchell, Sara N; Moore, Wendy; Murphy, Katherine A; Naumenko, Anastasia N; Nolan, Tony; Novoa, Eva M; O'Loughlin, Samantha; Oringanje, Chioma; Oshaghi, Mohammad A; Pakpour, Nazzy; Papathanos, Philippos A; Peery, Ashley N; Povelones, Michael; Prakash, Anil; Price, David P; Rajaraman, Ashok; Reimer, Lisa J; Rinker, David C; Rokas, Antonis; Russell, Tanya L; Sagnon, N'Fale; Sharakhova, Maria V; Shea, Terrance; Simão, Felipe A; Simard, Frederic; Slotman, Michel A; Somboon, Pradya; Stegniy, Vladimir; Struchiner, Claudio J; Thomas, Gregg W C; Tojo, Marta; Topalis, Pantelis; Tubio, José M C; Unger, Maria F; Vontas, John; Walton, Catherine; Wilding, Craig S; Willis, Judith H; Wu, Yi-Chieh; Yan, Guiyun; Zdobnov, Evgeny M; Zhou, Xiaofan; Catteruccia, Flaminia; Christophides, George K; Collins, Frank H; Cornman, Robert S; Crisanti, Andrea; Donnelly, Martin J; Emrich, Scott J; Fontaine, Michael C; Gelbart, William; Hahn, Matthew W; Hansen, Immo A; Howell, Paul I; Kafatos, Fotis C; Kellis, Manolis; Lawson, Daniel; Louis, Christos; Luckhart, Shirley; Muskavitch, Marc A T; Ribeiro, José M; Riehle, Michael A; Sharakhov, Igor V; Tu, Zhijian; Zwiebel, Laurence J; Besansky, Nora J.
In:
Science (New York, N.Y.), Vol. 347, No. 6217, 1258522, 02.01.2015.
Research output: Contribution to journal › Article › peer-review
Harvard
Neafsey, DE, Waterhouse, RM, Abai, MR, Aganezov, SS, Alekseyev, MA, Allen, JE, Amon, J, Arcà, B, Arensburger, P, Artemov, G, Assour, LA, Basseri, H, Berlin, A, Birren, BW, Blandin, SA, Brockman, AI, Burkot, TR, Burt, A, Chan, CS, Chauve, C, Chiu, JC, Christensen, M, Costantini, C, Davidson, VLM, Deligianni, E, Dottorini, T, Dritsou, V, Gabriel, SB, Guelbeogo, WM, Hall, AB, Han, MV, Hlaing, T, Hughes, DST, Jenkins, AM, Jiang, X, Jungreis, I, Kakani, EG, Kamali, M, Kemppainen, P, Kennedy, RC, Kirmitzoglou, IK, Koekemoer, LL, Laban, N, Langridge, N, Lawniczak, MKN, Lirakis, M, Lobo, NF, Lowy, E, MacCallum, RM, Mao, C, Maslen, G, Mbogo, C, McCarthy, J, Michel, K, Mitchell, SN, Moore, W, Murphy, KA, Naumenko, AN, Nolan, T, Novoa, EM, O'Loughlin, S, Oringanje, C, Oshaghi, MA, Pakpour, N, Papathanos, PA, Peery, AN, Povelones, M, Prakash, A, Price, DP, Rajaraman, A, Reimer, LJ, Rinker, DC, Rokas, A, Russell, TL, Sagnon, NF, Sharakhova, MV, Shea, T, Simão, FA, Simard, F, Slotman, MA, Somboon, P, Stegniy, V, Struchiner, CJ, Thomas, GWC, Tojo, M, Topalis, P, Tubio, JMC, Unger, MF, Vontas, J
, Walton, C, Wilding, CS, Willis, JH, Wu, Y-C, Yan, G, Zdobnov, EM, Zhou, X, Catteruccia, F, Christophides, GK, Collins, FH, Cornman, RS, Crisanti, A, Donnelly, MJ, Emrich, SJ, Fontaine, MC, Gelbart, W, Hahn, MW, Hansen, IA, Howell, PI, Kafatos, FC, Kellis, M, Lawson, D, Louis, C, Luckhart, S, Muskavitch, MAT, Ribeiro, JM, Riehle, MA, Sharakhov, IV, Tu, Z, Zwiebel, LJ & Besansky, NJ 2015, '
Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.',
Science (New York, N.Y.), vol. 347, no. 6217, 1258522.
https://doi.org/10.1126/science.1258522APA
Neafsey, D. E., Waterhouse, R. M., Abai, M. R., Aganezov, S. S., Alekseyev, M. A., Allen, J. E., Amon, J., Arcà, B., Arensburger, P., Artemov, G., Assour, L. A., Basseri, H., Berlin, A., Birren, B. W., Blandin, S. A., Brockman, A. I., Burkot, T. R., Burt, A., Chan, C. S., ... Besansky, N. J. (2015).
Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. Science (New York, N.Y.),
347(6217), [1258522].
https://doi.org/10.1126/science.1258522Vancouver
Author
Neafsey, Daniel E ; Waterhouse, Robert M ; Abai, Mohammad R ; Aganezov, Sergey S ; Alekseyev, Max A ; Allen, James E ; Amon, James ; Arcà, Bruno ; Arensburger, Peter ; Artemov, Gleb ; Assour, Lauren A ; Basseri, Hamidreza ; Berlin, Aaron ; Birren, Bruce W ; Blandin, Stephanie A ; Brockman, Andrew I ; Burkot, Thomas R ; Burt, Austin ; Chan, Clara S ; Chauve, Cedric ; Chiu, Joanna C ; Christensen, Mikkel ; Costantini, Carlo ; Davidson, Victoria L M ; Deligianni, Elena ; Dottorini, Tania ; Dritsou, Vicky ; Gabriel, Stacey B ; Guelbeogo, Wamdaogo M ; Hall, Andrew B ; Han, Mira V ; Hlaing, Thaung ; Hughes, Daniel S T ; Jenkins, Adam M ; Jiang, Xiaofang ; Jungreis, Irwin ; Kakani, Evdoxia G ; Kamali, Maryam ; Kemppainen, Petri ; Kennedy, Ryan C ; Kirmitzoglou, Ioannis K ; Koekemoer, Lizette L ; Laban, Njoroge ; Langridge, Nicholas ; Lawniczak, Mara K N ; Lirakis, Manolis ; Lobo, Neil F ; Lowy, Ernesto ; MacCallum, Robert M ; Mao, Chunhong ; Maslen, Gareth ; Mbogo, Charles ; McCarthy, Jenny ; Michel, Kristin ; Mitchell, Sara N ; Moore, Wendy ; Murphy, Katherine A ; Naumenko, Anastasia N ; Nolan, Tony ; Novoa, Eva M ; O'Loughlin, Samantha ; Oringanje, Chioma ; Oshaghi, Mohammad A ; Pakpour, Nazzy ; Papathanos, Philippos A ; Peery, Ashley N ; Povelones, Michael ; Prakash, Anil ; Price, David P ; Rajaraman, Ashok ; Reimer, Lisa J ; Rinker, David C ; Rokas, Antonis ; Russell, Tanya L ; Sagnon, N'Fale ; Sharakhova, Maria V ; Shea, Terrance ; Simão, Felipe A ; Simard, Frederic ; Slotman, Michel A ; Somboon, Pradya ; Stegniy, Vladimir ; Struchiner, Claudio J ; Thomas, Gregg W C ; Tojo, Marta ; Topalis, Pantelis ; Tubio, José M C ; Unger, Maria F ; Vontas, John
; Walton, Catherine ; Wilding, Craig S ; Willis, Judith H ; Wu, Yi-Chieh ; Yan, Guiyun ; Zdobnov, Evgeny M ; Zhou, Xiaofan ; Catteruccia, Flaminia ; Christophides, George K ; Collins, Frank H ; Cornman, Robert S ; Crisanti, Andrea ; Donnelly, Martin J ; Emrich, Scott J ; Fontaine, Michael C ; Gelbart, William ; Hahn, Matthew W ; Hansen, Immo A ; Howell, Paul I ; Kafatos, Fotis C ; Kellis, Manolis ; Lawson, Daniel ; Louis, Christos ; Luckhart, Shirley ; Muskavitch, Marc A T ; Ribeiro, José M ; Riehle, Michael A ; Sharakhov, Igor V ; Tu, Zhijian ; Zwiebel, Laurence J ; Besansky, Nora J. /
Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. In:
Science (New York, N.Y.). 2015 ; Vol. 347, No. 6217.
Bibtex
@article{abc026c38df249c78db1fbb4ef29f7cd,
title = "Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.",
abstract = "Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.",
author = "Neafsey, {Daniel E} and Waterhouse, {Robert M} and Abai, {Mohammad R} and Aganezov, {Sergey S} and Alekseyev, {Max A} and Allen, {James E} and James Amon and Bruno Arc{\`a} and Peter Arensburger and Gleb Artemov and Assour, {Lauren A} and Hamidreza Basseri and Aaron Berlin and Birren, {Bruce W} and Blandin, {Stephanie A} and Brockman, {Andrew I} and Burkot, {Thomas R} and Austin Burt and Chan, {Clara S} and Cedric Chauve and Chiu, {Joanna C} and Mikkel Christensen and Carlo Costantini and Davidson, {Victoria L M} and Elena Deligianni and Tania Dottorini and Vicky Dritsou and Gabriel, {Stacey B} and Guelbeogo, {Wamdaogo M} and Hall, {Andrew B} and Han, {Mira V} and Thaung Hlaing and Hughes, {Daniel S T} and Jenkins, {Adam M} and Xiaofang Jiang and Irwin Jungreis and Kakani, {Evdoxia G} and Maryam Kamali and Petri Kemppainen and Kennedy, {Ryan C} and Kirmitzoglou, {Ioannis K} and Koekemoer, {Lizette L} and Njoroge Laban and Nicholas Langridge and Lawniczak, {Mara K N} and Manolis Lirakis and Lobo, {Neil F} and Ernesto Lowy and MacCallum, {Robert M} and Chunhong Mao and Gareth Maslen and Charles Mbogo and Jenny McCarthy and Kristin Michel and Mitchell, {Sara N} and Wendy Moore and Murphy, {Katherine A} and Naumenko, {Anastasia N} and Tony Nolan and Novoa, {Eva M} and Samantha O'Loughlin and Chioma Oringanje and Oshaghi, {Mohammad A} and Nazzy Pakpour and Papathanos, {Philippos A} and Peery, {Ashley N} and Michael Povelones and Anil Prakash and Price, {David P} and Ashok Rajaraman and Reimer, {Lisa J} and Rinker, {David C} and Antonis Rokas and Russell, {Tanya L} and N'Fale Sagnon and Sharakhova, {Maria V} and Terrance Shea and Sim{\~a}o, {Felipe A} and Frederic Simard and Slotman, {Michel A} and Pradya Somboon and Vladimir Stegniy and Struchiner, {Claudio J} and Thomas, {Gregg W C} and Marta Tojo and Pantelis Topalis and Tubio, {Jos{\'e} M C} and Unger, {Maria F} and John Vontas and Catherine Walton and Wilding, {Craig S} and Willis, {Judith H} and Yi-Chieh Wu and Guiyun Yan and Zdobnov, {Evgeny M} and Xiaofan Zhou and Flaminia Catteruccia and Christophides, {George K} and Collins, {Frank H} and Cornman, {Robert S} and Andrea Crisanti and Donnelly, {Martin J} and Emrich, {Scott J} and Fontaine, {Michael C} and William Gelbart and Hahn, {Matthew W} and Hansen, {Immo A} and Howell, {Paul I} and Kafatos, {Fotis C} and Manolis Kellis and Daniel Lawson and Christos Louis and Shirley Luckhart and Muskavitch, {Marc A T} and Ribeiro, {Jos{\'e} M} and Riehle, {Michael A} and Sharakhov, {Igor V} and Zhijian Tu and Zwiebel, {Laurence J} and Besansky, {Nora J}",
note = "R01 AI063508, NIAID NIH HHS, United StatesR01 AI073745, NIAID NIH HHS, United StatesR01 AI076584, NIAID NIH HHS, United StatesR01 AI080799, NIAID NIH HHS, United StatesR01 AI104956, NIAID NIH HHS, United StatesR21 AI101459, NIAID NIH HHS, United StatesR56 AI107263, NIAID NIH HHS, United StatesSC1 AI109055, NIAID NIH HHS, United StatesU19 AI089686, NIAID NIH HHS, United StatesU54 HG003067, NHGRI NIH HHS, United States",
year = "2015",
month = jan,
day = "2",
doi = "10.1126/science.1258522",
language = "English",
volume = "347",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science (A A A S)",
number = "6217",
}
RIS
TY - JOUR
T1 - Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes.
AU - Neafsey, Daniel E
AU - Waterhouse, Robert M
AU - Abai, Mohammad R
AU - Aganezov, Sergey S
AU - Alekseyev, Max A
AU - Allen, James E
AU - Amon, James
AU - Arcà, Bruno
AU - Arensburger, Peter
AU - Artemov, Gleb
AU - Assour, Lauren A
AU - Basseri, Hamidreza
AU - Berlin, Aaron
AU - Birren, Bruce W
AU - Blandin, Stephanie A
AU - Brockman, Andrew I
AU - Burkot, Thomas R
AU - Burt, Austin
AU - Chan, Clara S
AU - Chauve, Cedric
AU - Chiu, Joanna C
AU - Christensen, Mikkel
AU - Costantini, Carlo
AU - Davidson, Victoria L M
AU - Deligianni, Elena
AU - Dottorini, Tania
AU - Dritsou, Vicky
AU - Gabriel, Stacey B
AU - Guelbeogo, Wamdaogo M
AU - Hall, Andrew B
AU - Han, Mira V
AU - Hlaing, Thaung
AU - Hughes, Daniel S T
AU - Jenkins, Adam M
AU - Jiang, Xiaofang
AU - Jungreis, Irwin
AU - Kakani, Evdoxia G
AU - Kamali, Maryam
AU - Kemppainen, Petri
AU - Kennedy, Ryan C
AU - Kirmitzoglou, Ioannis K
AU - Koekemoer, Lizette L
AU - Laban, Njoroge
AU - Langridge, Nicholas
AU - Lawniczak, Mara K N
AU - Lirakis, Manolis
AU - Lobo, Neil F
AU - Lowy, Ernesto
AU - MacCallum, Robert M
AU - Mao, Chunhong
AU - Maslen, Gareth
AU - Mbogo, Charles
AU - McCarthy, Jenny
AU - Michel, Kristin
AU - Mitchell, Sara N
AU - Moore, Wendy
AU - Murphy, Katherine A
AU - Naumenko, Anastasia N
AU - Nolan, Tony
AU - Novoa, Eva M
AU - O'Loughlin, Samantha
AU - Oringanje, Chioma
AU - Oshaghi, Mohammad A
AU - Pakpour, Nazzy
AU - Papathanos, Philippos A
AU - Peery, Ashley N
AU - Povelones, Michael
AU - Prakash, Anil
AU - Price, David P
AU - Rajaraman, Ashok
AU - Reimer, Lisa J
AU - Rinker, David C
AU - Rokas, Antonis
AU - Russell, Tanya L
AU - Sagnon, N'Fale
AU - Sharakhova, Maria V
AU - Shea, Terrance
AU - Simão, Felipe A
AU - Simard, Frederic
AU - Slotman, Michel A
AU - Somboon, Pradya
AU - Stegniy, Vladimir
AU - Struchiner, Claudio J
AU - Thomas, Gregg W C
AU - Tojo, Marta
AU - Topalis, Pantelis
AU - Tubio, José M C
AU - Unger, Maria F
AU - Vontas, John
AU - Walton, Catherine
AU - Wilding, Craig S
AU - Willis, Judith H
AU - Wu, Yi-Chieh
AU - Yan, Guiyun
AU - Zdobnov, Evgeny M
AU - Zhou, Xiaofan
AU - Catteruccia, Flaminia
AU - Christophides, George K
AU - Collins, Frank H
AU - Cornman, Robert S
AU - Crisanti, Andrea
AU - Donnelly, Martin J
AU - Emrich, Scott J
AU - Fontaine, Michael C
AU - Gelbart, William
AU - Hahn, Matthew W
AU - Hansen, Immo A
AU - Howell, Paul I
AU - Kafatos, Fotis C
AU - Kellis, Manolis
AU - Lawson, Daniel
AU - Louis, Christos
AU - Luckhart, Shirley
AU - Muskavitch, Marc A T
AU - Ribeiro, José M
AU - Riehle, Michael A
AU - Sharakhov, Igor V
AU - Tu, Zhijian
AU - Zwiebel, Laurence J
AU - Besansky, Nora J
N1 - R01 AI063508, NIAID NIH HHS, United StatesR01 AI073745, NIAID NIH HHS, United StatesR01 AI076584, NIAID NIH HHS, United StatesR01 AI080799, NIAID NIH HHS, United StatesR01 AI104956, NIAID NIH HHS, United StatesR21 AI101459, NIAID NIH HHS, United StatesR56 AI107263, NIAID NIH HHS, United StatesSC1 AI109055, NIAID NIH HHS, United StatesU19 AI089686, NIAID NIH HHS, United StatesU54 HG003067, NHGRI NIH HHS, United States
PY - 2015/1/2
Y1 - 2015/1/2
N2 - Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
AB - Variation in vectorial capacity for human malaria among Anopheles mosquito species is determined by many factors, including behavior, immunity, and life history. To investigate the genomic basis of vectorial capacity and explore new avenues for vector control, we sequenced the genomes of 16 anopheline mosquito species from diverse locations spanning ~100 million years of evolution. Comparative analyses show faster rates of gene gain and loss, elevated gene shuffling on the X chromosome, and more intron losses, relative to Drosophila. Some determinants of vectorial capacity, such as chemosensory genes, do not show elevated turnover but instead diversify through protein-sequence changes. This dynamism of anopheline genes and genomes may contribute to their flexible capacity to take advantage of new ecological niches, including adapting to humans as primary hosts.
U2 - 10.1126/science.1258522
DO - 10.1126/science.1258522
M3 - Article
C2 - 25554792
VL - 347
JO - Science
JF - Science
SN - 0036-8075
IS - 6217
M1 - 1258522
ER -
