Monoamine oxidase-ω-transaminase cascade for the deracemisation and dealkylation of amines

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Abstract

Herein we report a one-pot protocol for the deracemisation of chiral benzylic amines employing a novel monoamine oxidase–ω-transaminase cascade, allowing access to enantiopure compounds in >99 % ee. We also demonstrate that the same enzymatic cascade can be employed for the dealkylation of secondary amines with >99 % conversion.

Bibliographical metadata

Original languageEnglish
Pages (from-to)992-995
JournalChemCatChem
Volume6
Issue number4
DOIs
Publication statusPublished - 2014