Monoamine Oxidase (MAO-N) Whole Cell Biocatalyzed Aromatization of 1,2,5,6-Tetrahydropyridines into Pyridines

Research output: Contribution to journalArticle

  • External authors:
  • Anita Toscani
  • Caterina Risi
  • Gary W. Black
  • Nicola L. Brown
  • Ali Shaaban
  • Daniele Castagnolo

Abstract

A sustainable MAO-N biocatalyzed process for the synthesis of pyridines from aliphatic tetrahydropyridines (THP) has been developed. Pyridine compounds were synthesized under mild reaction conditions and with high conversion, exploiting MAO-N whole cells as aromatizing biocatalysts. The kinetic profile of the whole cell biocatalytic transformation was finally investigated via in situ 19F NMR.

Bibliographical metadata

Original languageEnglish
Pages (from-to)8781-8787
Number of pages6
JournalACS Catalysis
Volume8
Issue number9
Early online date7 Aug 2018
DOIs
Publication statusPublished - 7 Sep 2018