Molecular and cellular processes underlying the hallmarks of head and neck cancerCitation formats

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Molecular and cellular processes underlying the hallmarks of head and neck cancer. / Bernstein, Jonathan M.; Bernstein, Clare R.; West, Catharine M L; Homer, Jarrod J.

In: European Archives of Oto-Rhino-Laryngology, Vol. 270, No. 10, 09.2013, p. 2585-2593.

Research output: Contribution to journalArticle

Harvard

Bernstein, JM, Bernstein, CR, West, CML & Homer, JJ 2013, 'Molecular and cellular processes underlying the hallmarks of head and neck cancer', European Archives of Oto-Rhino-Laryngology, vol. 270, no. 10, pp. 2585-2593. https://doi.org/10.1007/s00405-012-2323-x

APA

Bernstein, J. M., Bernstein, C. R., West, C. M. L., & Homer, J. J. (2013). Molecular and cellular processes underlying the hallmarks of head and neck cancer. European Archives of Oto-Rhino-Laryngology, 270(10), 2585-2593. https://doi.org/10.1007/s00405-012-2323-x

Vancouver

Bernstein JM, Bernstein CR, West CML, Homer JJ. Molecular and cellular processes underlying the hallmarks of head and neck cancer. European Archives of Oto-Rhino-Laryngology. 2013 Sep;270(10):2585-2593. https://doi.org/10.1007/s00405-012-2323-x

Author

Bernstein, Jonathan M. ; Bernstein, Clare R. ; West, Catharine M L ; Homer, Jarrod J. / Molecular and cellular processes underlying the hallmarks of head and neck cancer. In: European Archives of Oto-Rhino-Laryngology. 2013 ; Vol. 270, No. 10. pp. 2585-2593.

Bibtex

@article{8cf156c0322c4cef9c81bf1c3d43d356,
title = "Molecular and cellular processes underlying the hallmarks of head and neck cancer",
abstract = "The hallmarks of cancer were updated by Hanahan and Weinberg in 2011. Here we discuss the updated hallmarks in relation to what is known of the molecular and cellular processes underlying the development of head and neck squamous cell carcinoma (HNSCC). Several mechanisms are described, and recent surveys of HNSCC suggest a limited number of mutations, from which more mechanisms may emerge. There are also epigenetic changes to the control of normal processes. More than one mechanism underlies each hallmark. Processes essential to the development of HNSCC need not be essential to the proliferation of the fully developed tumour. Attention is paid to the emerging hallmarks, deregulation of cellular energy metabolism and evasion of immune destruction, and enabling characteristics, genome instability and mutation and tumour-promoting inflammation. HNSCC may adapt to hypoxia, suppress HLA expression, and express Toll-like receptors to facilitate inflammation, which support the proliferation of the tumour. {\circledC} 2012 Springer-Verlag Berlin Heidelberg.",
keywords = "Hallmarks of cancer, Head and neck cancer, Molecular biology, Squamous cell carcinoma",
author = "Bernstein, {Jonathan M.} and Bernstein, {Clare R.} and West, {Catharine M L} and Homer, {Jarrod J.}",
year = "2013",
month = "9",
doi = "10.1007/s00405-012-2323-x",
language = "English",
volume = "270",
pages = "2585--2593",
journal = "European Archives of Oto-Rhino-Laryngology",
issn = "0937-4477",
publisher = "Springer Nature",
number = "10",

}

RIS

TY - JOUR

T1 - Molecular and cellular processes underlying the hallmarks of head and neck cancer

AU - Bernstein, Jonathan M.

AU - Bernstein, Clare R.

AU - West, Catharine M L

AU - Homer, Jarrod J.

PY - 2013/9

Y1 - 2013/9

N2 - The hallmarks of cancer were updated by Hanahan and Weinberg in 2011. Here we discuss the updated hallmarks in relation to what is known of the molecular and cellular processes underlying the development of head and neck squamous cell carcinoma (HNSCC). Several mechanisms are described, and recent surveys of HNSCC suggest a limited number of mutations, from which more mechanisms may emerge. There are also epigenetic changes to the control of normal processes. More than one mechanism underlies each hallmark. Processes essential to the development of HNSCC need not be essential to the proliferation of the fully developed tumour. Attention is paid to the emerging hallmarks, deregulation of cellular energy metabolism and evasion of immune destruction, and enabling characteristics, genome instability and mutation and tumour-promoting inflammation. HNSCC may adapt to hypoxia, suppress HLA expression, and express Toll-like receptors to facilitate inflammation, which support the proliferation of the tumour. © 2012 Springer-Verlag Berlin Heidelberg.

AB - The hallmarks of cancer were updated by Hanahan and Weinberg in 2011. Here we discuss the updated hallmarks in relation to what is known of the molecular and cellular processes underlying the development of head and neck squamous cell carcinoma (HNSCC). Several mechanisms are described, and recent surveys of HNSCC suggest a limited number of mutations, from which more mechanisms may emerge. There are also epigenetic changes to the control of normal processes. More than one mechanism underlies each hallmark. Processes essential to the development of HNSCC need not be essential to the proliferation of the fully developed tumour. Attention is paid to the emerging hallmarks, deregulation of cellular energy metabolism and evasion of immune destruction, and enabling characteristics, genome instability and mutation and tumour-promoting inflammation. HNSCC may adapt to hypoxia, suppress HLA expression, and express Toll-like receptors to facilitate inflammation, which support the proliferation of the tumour. © 2012 Springer-Verlag Berlin Heidelberg.

KW - Hallmarks of cancer

KW - Head and neck cancer

KW - Molecular biology

KW - Squamous cell carcinoma

U2 - 10.1007/s00405-012-2323-x

DO - 10.1007/s00405-012-2323-x

M3 - Article

VL - 270

SP - 2585

EP - 2593

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

SN - 0937-4477

IS - 10

ER -