Modulation of Fast Narrowband Oscillations in the Mouse Retina and dLGN According to Background Light Intensity

Research output: Contribution to journalArticle

  • External authors:
  • Riccardo Storchi
  • Robert Bedford
  • Franck Martial
  • Jonathan Wynne

Abstract

Background light intensity (irradiance) substantially impacts the visual code in the early visual system at synaptic and single-neuron levels, but its influence on population activity is largely unexplored. We show that fast narrowband oscillations, an important feature of population activity, systematically increase in amplitude as a function of irradiance in both anesthetized and awake, freely moving mice and at the level of the retina and dorsal lateral geniculate nucleus (dLGN). Narrowband coherence increases with irradiance across large areas of the dLGN, but especially for neighboring units. The spectral sensitivity of these effects and their substantial reduction in melanopsin knockout animals indicate a contribution from inner retinal photoreceptors. At bright backgrounds, narrowband coherence allows pooling of single-unit responses to become a viable strategy for enhancing visual signals within its frequency range.

Bibliographical metadata

Original languageEnglish
Pages (from-to)299-307
Number of pages9
JournalNeuron
Volume93
Issue number2
Early online date18 Jan 2017
DOIs
StatePublished - 2017