Modelling and simulation in the development and use of anti-cancer agents: An underused tool?

Research output: Contribution to journalArticle

  • External authors:
  • Ferdinand Rombout
  • Mats Karlsson
  • Anthony Man
  • France Mentré
  • Peter Nygren
  • Amy Racine
  • Hans Schaefer
  • Jean Louis Steimer
  • Iñaki Troconiz
  • Achiel Van Peer


To help identify the role of modelling and simulation in the development of anti-cancer agents, their main advantages and the obstacles to their rational use, an expert meeting was organized by COST B15. This manuscript presents a synthesis of views expressed at that meeting and indicates future directions. The manuscript also shows some examples where modelling and simulation have proven to be of relevant value in the drug development process for anti-cancer agents. © 2005 Springer Science+Business Media, Inc.

Bibliographical metadata

Original languageEnglish
Pages (from-to)419-440
Number of pages21
JournalJournal of pharmacokinetics and pharmacodynamics
Issue number6
Publication statusPublished - Dec 2004