Micro-haemodynamics at the maternal fetal interface: experimental, theoretical and clinical perspectivesCitation formats

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Micro-haemodynamics at the maternal fetal interface: experimental, theoretical and clinical perspectives. / Zhou, Qi; Doman, Eleanor; Schirrmann, Kerstin; Chen, Qi; Seed, Ellie; Johnstone, Edward; Selvaganapathy, Ravi; Juel, Anne; Jensen, Oliver; Bernabeu, Miguel O.; Kruger, Timm; Chernyavsky, Igor.

In: Current Opinion in Biomedical Engineering, 06.2022.

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@article{9bef426a6b5d4cf18f33981c224f5767,
title = "Micro-haemodynamics at the maternal fetal interface: experimental, theoretical and clinical perspectives",
abstract = "The placenta is a vital interface between the mother and her developing fetus. Micro-haemodynamics of the placenta, where the particulate nature of blood flow cannot be ignored, mediates the relationship between the organ's structure and its function. However, the placenta's complex architecture and its relation to pregnancy pathologies remain poorly understood. This review covers current challenges in characterising placental micro-haemodynamics. Recent progress in three-dimensional multiscale imaging has stimulated development of image-based theoretical models, but existing approaches do not fully harness the available data, and new tools are needed for assimilation of complex imaging datasets. Although the placenta at term is available for in vivo imaging or ex vivo experimentation, insight into placental micro-rheology is limited, necessitating the use of biomimetic models. Micro fluidic approaches offer opportunities for well-controlled characterisation of micro-rheology in complex geometries, but challenges remain in robust fabrication of these systems. Recent advances in high-performance simulations for suspension flows enable parametrisation of key physical processes at the micro-scale. Future progress can be made by optimising computational architecture and integrating micro-haemodynamics with solute transport. Both experimental and computational approaches require translation to the organ scale. New upscaling approaches will need to accommodate non-local interactions in microvascular network flows and address the lack of clear scale-separation across the placental architecture. Together, recent advances in cross-disciplinary imaging and modelling over the last ten years have opened a pathway for an in silico human placenta, accelerating the development of precision obstetrics medicine in the next decade.",
author = "Qi Zhou and Eleanor Doman and Kerstin Schirrmann and Qi Chen and Ellie Seed and Edward Johnstone and Ravi Selvaganapathy and Anne Juel and Oliver Jensen and Bernabeu, {Miguel O.} and Timm Kruger and Igor Chernyavsky",
year = "2022",
month = jun,
doi = "https://doi.org/10.1016/j.cobme.2022.100387",
language = "English",
journal = "Current Opinion in Biomedical Engineering",
issn = "2468-4511",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Micro-haemodynamics at the maternal fetal interface: experimental, theoretical and clinical perspectives

AU - Zhou, Qi

AU - Doman, Eleanor

AU - Schirrmann, Kerstin

AU - Chen, Qi

AU - Seed, Ellie

AU - Johnstone, Edward

AU - Selvaganapathy, Ravi

AU - Juel, Anne

AU - Jensen, Oliver

AU - Bernabeu, Miguel O.

AU - Kruger, Timm

AU - Chernyavsky, Igor

PY - 2022/6

Y1 - 2022/6

N2 - The placenta is a vital interface between the mother and her developing fetus. Micro-haemodynamics of the placenta, where the particulate nature of blood flow cannot be ignored, mediates the relationship between the organ's structure and its function. However, the placenta's complex architecture and its relation to pregnancy pathologies remain poorly understood. This review covers current challenges in characterising placental micro-haemodynamics. Recent progress in three-dimensional multiscale imaging has stimulated development of image-based theoretical models, but existing approaches do not fully harness the available data, and new tools are needed for assimilation of complex imaging datasets. Although the placenta at term is available for in vivo imaging or ex vivo experimentation, insight into placental micro-rheology is limited, necessitating the use of biomimetic models. Micro fluidic approaches offer opportunities for well-controlled characterisation of micro-rheology in complex geometries, but challenges remain in robust fabrication of these systems. Recent advances in high-performance simulations for suspension flows enable parametrisation of key physical processes at the micro-scale. Future progress can be made by optimising computational architecture and integrating micro-haemodynamics with solute transport. Both experimental and computational approaches require translation to the organ scale. New upscaling approaches will need to accommodate non-local interactions in microvascular network flows and address the lack of clear scale-separation across the placental architecture. Together, recent advances in cross-disciplinary imaging and modelling over the last ten years have opened a pathway for an in silico human placenta, accelerating the development of precision obstetrics medicine in the next decade.

AB - The placenta is a vital interface between the mother and her developing fetus. Micro-haemodynamics of the placenta, where the particulate nature of blood flow cannot be ignored, mediates the relationship between the organ's structure and its function. However, the placenta's complex architecture and its relation to pregnancy pathologies remain poorly understood. This review covers current challenges in characterising placental micro-haemodynamics. Recent progress in three-dimensional multiscale imaging has stimulated development of image-based theoretical models, but existing approaches do not fully harness the available data, and new tools are needed for assimilation of complex imaging datasets. Although the placenta at term is available for in vivo imaging or ex vivo experimentation, insight into placental micro-rheology is limited, necessitating the use of biomimetic models. Micro fluidic approaches offer opportunities for well-controlled characterisation of micro-rheology in complex geometries, but challenges remain in robust fabrication of these systems. Recent advances in high-performance simulations for suspension flows enable parametrisation of key physical processes at the micro-scale. Future progress can be made by optimising computational architecture and integrating micro-haemodynamics with solute transport. Both experimental and computational approaches require translation to the organ scale. New upscaling approaches will need to accommodate non-local interactions in microvascular network flows and address the lack of clear scale-separation across the placental architecture. Together, recent advances in cross-disciplinary imaging and modelling over the last ten years have opened a pathway for an in silico human placenta, accelerating the development of precision obstetrics medicine in the next decade.

U2 - https://doi.org/10.1016/j.cobme.2022.100387

DO - https://doi.org/10.1016/j.cobme.2022.100387

M3 - Article

JO - Current Opinion in Biomedical Engineering

JF - Current Opinion in Biomedical Engineering

SN - 2468-4511

ER -